Bone Health in Women With Polycystic Ovary Syndrome: A Narrative Review |
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| Institution: | 1. Centro de Investigación en Alimentación y Desarrollo, A.C. Coordinación de Nutrición, Hermosillo, Sonora, México;2. Departamento de Ciencias de la Salud, Universidad Autónoma de Ciudad Juárez, Instituto de Ciencias Biomédicas, Ciudad Juárez, Chihuahua, México;3. Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México;1. Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland;2. University of Wisconsin Osteoporosis Clinical Research Program, Madison, WI, USA;3. Research and Development Department, Medimaps, Bordeaux, France;1. Department of Basic Medicine, Zhangzhou Health Vocational College, Zhangzhou, 363000 Fujian Province, China;2. Department of Orthopaedic Surgery, Dongnan Hospital of Xiamen University, School of Medicine, Xiamen University, Zhangzhou, 363000 Fujian Province, China;1. Azienda Ospedaliera per L''Emergenza \"Cannizzaro\", U.O.C Ortopedia e Traumatologia, Catania. Via Messina 829, 95126 Catania;2. Department of Biomedical, Surgical and Dental sciences. Università degli Studi di Milano. Via della Commenda 10, 20122, Milan, Italy;3. Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milan, Italy;4. 1°Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Piazza Cardinal Ferrari 1, 20122 Milan, Italy;5. U.O.C. WEEK SURGERY di Ortopedia e Traumatologia, Azienda Socio-Sanitaria Territoriale Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Piazza Cardinal Ferrari 1, 20122 Milan, Italy;1. Department of Medicine, Faculty of Medicine, University of Ruhuna, Sri Lanka;2. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka;1. Department of Radiology and Diagnostic Imaging, Rede SARAH de Hospitais de Reabilitação, Av. Amazonas, 5953. Gameleira, 30510-000, Belo Horizonte, MG, Brazil;2. Department of Internal Medicine, Rede SARAH de Hospitais de Reabilitação, Belo Horizonte, MG, Brazil;3. Department of Pathology, Rede SARAH de Hospitais de Reabilitação, Belo Horizonte, MG, Brazil;4. Department of Spinal Injury Rehabilitation, Rede SARAH de Hospitais de Reabilitação, Belo Horizonte, MG, Brazil |
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| Abstract: | Bone as an active connective and endocrine tissue is influenced by hormones, physical activity, inflammatory factors, minerals, dietary components, and body weight. Bone fractures are a major cause of decreased quality of life and mortality in humans. Polycystic ovary syndrome (PCOS), is one of the most common endocrine disorders in women of reproductive age worldwide. PCOS is associated with disturbances in androgen and estrogen levels, insulin resistance (IR), obesity, as well as low-grade chronic inflammation, and gut microbiota (GM) dysbiosis, all of which may negatively or positively affect bone metabolism. However, it has not yet been well clarified whether PCOS is bone-protective or bone-destructive. This study aimed to review the association between bone health and PCOS, and summarize its related factors. PubMed, Scopus, and Web of Science databases were searched to retrieve relevant English publications investigating the relationship between bone health and PCOS. Several disorders associated with PCOS can negatively or positively affect bone metabolism. Despite some positive effects of insulin, androgens, estrogens, and obesity on bone, IR, estrogen deficiency, low-grade chronic inflammation, and GM dysbiosis may adversely affect the bone metabolism in PCOS women. Studies comparing bone mineral density or bone metabolism and the risk of bone fractures in women with PCOS have controversial results. Further studies are required to understand the mechanisms underlying bone metabolism in PCOS subjects. Moreover, prospective studies are needed to estimate the risk of bone fractures and osteoporosis in PCOS subjects. |
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