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A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut
Affiliation:1. Developmental Immunology Unit, Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Lund University, 22242 Lund, Sweden;2. Developmental Hematopoiesis Unit, Division of Molecular Hematology, Department of Laboratory Medicine, Lund Stem Cell Center, Lund University, 22242 Lund, Sweden;3. Immunology Section, Lund University, Lund 22184, Sweden;4. Mucosal Immunology Group, Department of Health Technology, Technical University of Denmark, Kemitorvet, 2800 Kgs. Lyngby, Denmark;5. Section for Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark (DTU), 2800 Kongens Lyngby, Denmark
Abstract:
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  • Keywords:B-1 cells  IgA  plasma cells  window of opportunity  B cell memory  early-life exposure  time-stamping  early-life-origin B cells  rotavirus  gut B cells
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