组织工程心脏瓣膜的研究现状与展望

心脏瓣膜病是常见的心脏病,心脏瓣膜置换术是治疗心脏瓣膜病的有效方法。目前所用的机械瓣和生物瓣均存在一定的缺点,探索和研究一种理想的人造心脏瓣膜,是心脏瓣膜外科领域所要解决的重大问题。随着组织工程技术的发展,组织工程心脏瓣膜被认为是一种潜在的理想的人造瓣膜,具有非常重要的临床应用前景,是目前心脏瓣膜外科领域重大研究课题。本文对近年来组织工程瓣膜支架材料、组织细胞来源和种植、体外预适应和在体动物试验等方面研究进行了评估,并指出目前研究中所存在的问题。

Current situation on tissue engineering heart valve research and its future

Valvular disease is a commonly seen heart disorder,valve replacement is an effective approach to treat valve disorders.Both the mechanic valves and bioprosthesis used now have their own defects,making it important for the cardio surgery field to develop some kind of ideal valves.With the development of tissue engineering techniques,the tissue engineering valves are thought to have great potential and bright clinical future,and now it has become a hot point in cardiac surgery.This article is to evaluate the frame materials,resource of tissue cells and implantation, in vitro pre adaptation testing and in vivo animal experiment results,and the existing problems are pointed out in the present study.