| 涎腺腺样囊性癌c—erbB—2癌基因产物的阴性表达及意义 |
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| 引用本文： | 史宏男 何荣根. 涎腺腺样囊性癌c—erbB—2癌基因产物的阴性表达及意义[J]. 上海口腔医学, 1998, 7(4): 187-189 |
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| 作者姓名： | 史宏男 何荣根 |
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| 作者单位： | 上海铁道大学附属甘泉医院口腔颌面外科!200061(史宏男)，上海第二医科大学口腔医学院口腔颌面外科教研室(何荣根) |
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| 基金项目： | 国家自然科学基金!39470755 |
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| 摘 要： | 目的 研究涎腺腺样囊性癌（ACC）c-erb B-2癌基因的表达及其意义。方法 采用抗c-erb B-2癌基因的单克隆抗体对25例（ACC）肿瘤标本和两个ACC细胞株进行免疫组化研究。结果各种类型的ACC和两个细胞株均呈阴性表达。结论提示c-erb B-2不能作为ACC恶性程度的标志。
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| 关 键 词： | 癌基因c-erbB-2 涎腺腺样囊性癌 免疫组织化学 |
Expresson of c-erb B-2 oncoprotein in salivary adenoid cystic carcinoma |
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| Shi Hongnan,He Ronggen. Expresson of c-erb B-2 oncoprotein in salivary adenoid cystic carcinoma[J]. Shanghai journal of stomatology, 1998, 7(4): 187-189 |
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| Authors: | Shi Hongnan He Ronggen |
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| Affiliation: | Department of Oral Maxillofacial Surgery,School of Stomatology,Shanghai Second Medical University.Shanghai 200011, China. |
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| Abstract: | Objective in order to analyze the correlation between immunohistochemical expression for c-erb B-2 oncoprotein and salivary adenoid cystic carcinoma (ACC ). Methods 25 cases of ACC and two ACC cell strain was studied immunohistochemically using a monoclone antibody against c-erb B-2 oncoprotein. Results No positive results were obtained in any cases and cell strains, but the invasive breast cancer expressed strong positive. Conclusion it demonstrated that c-erb B-2 expression can not be used as a predictive marker for prognosis of ACC. [ |
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| Keywords: | salivary adenoid cystic carcinoma (ACC) oncogene c-erbB-2 gene Immunohistochemistry |
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