接触二硫化碳男工血清性激素水平及尿代谢物含量分析

为探讨长期接触二硫化碳（ＣＳ２）的粘胶纺丝男工血清性激素及尿２－硫代－噻唑啶－４－羧酸（ＴＴＣＡ）水平，应用放射免疫法测定接触工人血清性激素水平及用高效液相色谱法测定工人班末尿中ＴＴＣＡ含量。以多功能气体红外监测仪定点连续监测车间ＣＳ２浓度为（１４．４０±４．６２）ｍｇ／ｍ３（６．０１～２５．３０ｍｇ／ｍ３），平均接触工龄为１０．４年。结果显示（１）接触组血清促卵泡激素〔ＦＳＨ：（１０．９４±７．３５）ＩＵ／Ｌ）〕明显高于对照组〔（７．５０±５．０７）ＩＵ／Ｌ〕；催乳素〔ＰＲＬ（５．７２±４．１８）ｎｇ／Ｌ〕则显著低于对照组〔（６．８９±４．６２）ｎｇ／Ｌ〕；血清促黄体激素（ＬＨ）、睾丸酮（Ｔ）等两组间均无统计学显著差异。但随着暴露工龄延长，ＨＬ含量明显下降。班的轮换不影响性激素水平。（２）在该接触浓度下工人班末尿ＴＴＣＡ为（１．０７２±１．０１３）ｍｇ／ｇ肌酐，随尿ＴＴＣＡ排出量增加，血清ＦＳＨ含量明显下降，存在接触－反应关系。本研究表明，现有接触水平对男工内分泌系统功能已造成一定损害。

Serum sex hormone and urinary metabolites of male workers exposed to carbon disulfide

Serum luteotropic hormone(LH), follicle-stimulating hormone (FSH), prolectin(PRL) and testosterone (T) were determined by radioimmunoassay methods in 50 workers exposed to carbon disulfide(CS2) in a viscose rayon factory. Urinary excretion of 2-thio-thiazolidine-4-carboxilic acid (TTCA) in workers by the end of work shift was analyzed with modified high-performance liquid chromatography. The working conditions of the factory had not been changed since 1950s. The concentration of CS2, determined by Multigas Monitor (type 1320) in workplace, was (14.4 +/- 4.62) mg/m3. The results showed that: (1) serum FSH of CS2 group (10.04 +/- 7.35)IU/L was significantly higher than that of control group (7.50 +/- 7.07 IU/L), PRL of CS2 group (5.72 +/- 4.18) ng/L was significantly lower than that of control group (6.89 +/- 4.64 ng/L). Serum LH was declined with the increase of time exposed to CS2, (2) urinary TTCA in CS2 group was 1.072 +/- 1.013 mg/g Cr. Serum FSH was declined with the increase of TTCA excretion. The results suggested that the function of endocrine system was disturbed in workers exposed to CS2.