新生儿窒息血清胆红素变化与脑损伤的相关性研究

目的探讨新生儿窒息血清胆红素变化与其脑损伤程度的相关性。方法收集我院足月窒息新生儿83例，其中轻度55例，重度28例；另选择同期足月正常新生儿50例为对照组。采用OLYMPUSAU640型生化分析仪动态检测胆红素水平变化，分析其与窒息后脑损伤的关系。结果出生后24h，轻度和重度窒息组新生儿皿清胆红素水平均明屁高于对照组（P〈0．05）；72h、7d时轻度和重度窒息组新生儿血清胆红素水平均明显低于对照组（P〈0．05或P〈0．01），且重度窒息组新生儿的血清胆红素水平明显低于轻度窒息组新生儿（P〈0．01）。出生后24h、72h、7d时脑损伤组患儿的血清胆红素水平均明显低于无脑损伤组（P〈0．05或P〈0．01）。结论血清胆红素参与了新生儿窒息的病理生理过程，且可能对窒息后脑损伤具有保护作用。

Relationship of Bilirubin Serum Level with Brain Damage in Neonatal Asphyxia

Objective To study the changes of bilirubin serum level and the relation to brain damage in neonatal asphyxia.Methods Dynamic variation of bilirubin serum level was monitored in 83 asphyxiated newborn infants and 50 nomlal infants,and the relation between the brain damage and bilirubin in neonatal asphyxia were analyzed.Results After birth 24h,the plasma bilirubin level of the mild and severe asphyxia groups was significantly higher than that of the control group(P<0.05).After birth 72h and 7d,the plasma bi...