| 人胃癌组织中fibulin-5的表达及其临床意义 |
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| 引用本文： | 文灿,董世武,余汇洋.人胃癌组织中fibulin-5的表达及其临床意义[J].中华消化外科杂志,2006,5(6):463-465. |
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| 作者姓名： | 文灿 董世武 余汇洋 |
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| 作者单位： | 1. 400038,重庆,第三军医大学基础医学部外科应用解剖与手术学教研室
2. 400038,重庆,第三军医大学基础医学部解剖学教研室 |
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| 基金项目： | 第三军医大学校管课题(2004) |
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| 摘 要： | 目的探讨fibulin-5在人胃癌组织中的表达及其临床意义。方法采用免疫组织化学染色结合图像分析法,对32例胃癌组织、癌旁组织及正常胃组织中fibulin-5的表达进行半定量分析。结果fibulin-5在胃癌组织中的表达强于癌旁组织和正常组织(P<0.05),且表达强度与癌组织的分化程度有关,低分化癌组织的fibulin-5表达强(P<0.05)。结论fibulin-5的表达可能与胃癌组织细胞的恶性转化及增殖有关。
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| 关 键 词： | fibulin-5 胃癌 免疫组织化学 |
| 文章编号： | 1671-4555(2006)06-0463-03 |
| 修稿时间： | 2006年6月20日 |
Expression and clinical significance of fibulin-5 in human gastric carcinoma |
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| WEN Can,DONG Shi-wu,YU Hui-yang.Expression and clinical significance of fibulin-5 in human gastric carcinoma[J].Chinese Journal of Digestive Surgery,2006,5(6):463-465. |
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| Authors: | WEN Can DONG Shi-wu YU Hui-yang |
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| Abstract: | Objective To investigate the expression and clinical significance of fibulin-5 in gastric carcinoma. Methods The expression of fibulin-5 in human gastric cancerous tissues, precancerous tissues and normal gastric tissue of 32 cases was semi-quantitatively examined by immunohistochemical stain combined with image analysis. Results The expression of fibulin-5 in human gastric cancerous tissues was significantly higher than that in precancerous tissues and normal gastric tissues (P<0.05), with expression relating differentiation degree of gastric cancerous tissues, ie, the lower differentiation of gastric cancerous tissue resulted in higher expression of fibulin-5 (P<0.05). Conclusion The expression of fibulin-5 may involve proliferation and malignant transformation of the gastric cancerous cells. |
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| Keywords: | Fibulin-5 Gastric cancer Immunohistochemistry |
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