血浆脑钠肽与急性心肌梗死临床及预后关系的研究

目的探讨血浆脑钠肽（brain natriuretic peptide,BNP）水平与急性心肌梗死（acute myocardial infarction,AMI）范围、左室功能及预后的关系。方法76例确诊为AMI的患者,入院后24h内检测血浆BNP,超声心动图测定左室射血分数（left ventricular ejection fraction,LVEF）,所有患者均随访6个月,观察血浆BNP浓度与AMI的范围、左室功能及预后的关系。结果血浆BNP水平与AMI面积呈正相关（P〈0.05）,与LVEF呈负相关（P〈0.05）,血浆BNP水平高的患者心血管事件发生率高（P〈0.05）。结论血浆BNP水平可反映AMI的严重程度;AMI范围越大,左室功能越差,BNP水平越高;BNP水平可作为心血管事件预测指标。

Relationship between Plasma Level of Brain Natriuretic Peptide and Clinical Manifestation and Prognosis of Patients with Acute Myocardial Infarction

Objective To observe the relationship between the plasma level of brain natriuretic peptide （BNP） and clinical manifestation of patients with acute myocardial infarction （AMI）. Methods 72 patients with AMI were enrolled in this study, The plasma level of BNP was measured and the left ventricular ejection fraction（LVEF） was evaluated by echocardiography within 24 hours after admission. All patients were followed up for six months. Results The plasma level of BNP in the patients with AMI had a positive correlation with infarction areas, and negative correlation with LVEF （ P 〈 0.05 ）. The clinical cardiac events occurred more frequently in the patients with higher BNP level. Conclusion The plasma level of BNP in patients with AMI might be a reliable biochemical marker which can objectively evaluate the degree and prognosis of the disease.