不同年龄成年人急性白血病形态学、免疫学及细胞遗传学分型比较 |
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引用本文: | 吴炜,邱国强,吴浩清,王志林. 不同年龄成年人急性白血病形态学、免疫学及细胞遗传学分型比较[J]. 白血病.淋巴瘤, 2010, 19(1): 344-346. DOI: 10.3760/cma.j.issn.1009-9921.2010.06.008 |
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作者姓名: | 吴炜 邱国强 吴浩清 王志林 |
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作者单位: | 常州市第一人民医院血液科,苏州大学附属第三医院,213003; |
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摘 要: | Objective To investigate the characters of morphology,immunology and cytogenetics of adult acute leukemia (AL) in different ages. Methods 172 cases of newly diagnosed adult AL were divided into two groups:the non-aged group (age<60 years) and the aged group ( age≥60 years). Morphology,immunology and cytogenetics between the two groups were compared. Results The incidence of M3 in aged AL was significantly lower than that in non-aged AL[6.0 %(3/50) vs 18.9 %(23/122),P <0.05]. The incidence of hypo-or extremely hypo-cellular AL in aged AL was significantly higher than that in non-aged AL[14.0 %(7/50) vs 4.1 %(5/122),P <0.05],but the incidence of hyper-or extremely hyper-cellular was significantly lower than that in non-aged AL[52.0 %(26/50) vs 73.8 %(90/122),P <0.05]. Among aged acute myeloid leukemia (AML),the incidence of lymphoid antigen positive AML (Ly+AML) was significantly higher than that in non-aged AML[63.4 %(26/41) vs 41.3 %(38/92),P <0.05]. The incidence of adverse karyotypes in aged AML was significantly higher than that in non-aged AML[33.3 %(11/33) vs 14.1 %(10/71),P <0.05].Conclusion Age is an important prognostic factor in AL. Generally,aged AL has poorer prognosis than nonaged AL.
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关 键 词: | 白血病 成年人 形态学 变态反应和免疫学 细胞遗传学 |
Comparison of morphology, immunology and cytogenetics in adult acute leukemia of different ages |
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Keywords: | LeukemiaAdultMorphologyAllergy and immunologyCytogenetics |
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