新疆维吾尔族阿尔茨海默病患者脑啡肽酶基因与载脂蛋白E基因多态性的关联分析

Objective To assess the association between the neprilysin (NEP) gene and apolipoprotein E (ApoE) gene polymorphisms and sporadic Alzheimer' disease (SAD) in Xinjiang Uygur population. Methods The polymorphisms of the NEP and ApoE gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 111 SAD patients and 117 healthy controls. Results (1) The frequency of the T allele in the NEP gene was significantly higher in the SAD patients than that in the controls (x2 =5.005, P＜0.05);and there was higher risk to develop SAD in the T allele carriers. (2) The frequency of the ApoE 4 ε4 allele was higher in the SAD patients than in the controls (x2 =4. 218,P＜0.05);and the ApoE 4 ε4 carriers had significantly increased risk of developing SAD. (3)No significant interaction was found between the NEP and ApoE polymorphisms in SAD patients.Conclusion The NEP and ApoE gene polymorphisms may be associated with SAD. NEP gene may be an independent genetic risk factor for SAD in Xinjiang Uygur population.

Association of the neprilysin and apolipoprotein E gene polymorphisms with Alzheimer's disease in Xinjiang Uygur population