Expression of TGF-β1 and the mechanism of invasiveness and metastasis induced by TGF-β1 in breast cancer |
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作者姓名: | 鲍健 吴正升 齐越 吴强 杨枫 |
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作者单位: | 安徽医科大学第三附属医院肿瘤科,合肥,230061;安徽医科大学病理学教研室,合肥,230061;安徽医科大学第三附属医院临床医学系,合肥,230061; |
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基金项目: | 安徽省高校青年教师资助汁划项目安徽省高校省级自然科学基金重点项目 |
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摘 要: | Objective To investigate the expression of MMP-2,TIMP-2,TGF-β1 and TGF-βRI and the relationship among them in breast cancer.Methods The protein expression of MMP-2,TIMP-2,TGF-β1 and TGF-β1R1 was detected on tissue chips by S-P immunohistochemical staining in 160 cases of breast carcinoma.Results The positive rates of TGF-β1,TGF-β1 mRNA,MMP-2,MMP-9,TIMP-1 and TIMP-2 expression were 73.7%,56.2%,96.9%,95.0%,87.5% and 89.4%,respectively.Axillary lymph node metastasis and TNM staging(P <0.01 and P <0.01,respectively)were positively correlated to the expression of TGF-β1.Relase-free survival of TGF-β1 positive group was lower than that of TGF-β1 negative group(P = 0.023).The expression of M MP-2 or M M P-9 was positively correlated to that of TGF-β1 (r=0.170,P<0.05;r =0.221,P<0.01)and was negatively correlated to that of TGF-β1 mRNA(r =-0.126,P >0.05;r = 0.019,P > 0.05).Conclusion The expression of TGF-β1 may be closely correlated with the invasion and metastasis of breast cancer.TGF-β1-induced invasiveness and metastasis of breast cancer cells are mediated by MMP-2 and MMP-9.
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关 键 词: | 乳腺肿瘤 转化生长因子 基质金属蛋白酶 组织金属蛋白酶抑制物 肿瘤侵袭 肿瘤转移 |
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