| 光动力学治疗对瘢痕成纤维细胞增殖及其细胞周期的影响 |
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| 引用本文： | 蔡宏,顾瑛,孙强,曾晶,李世龙. 光动力学治疗对瘢痕成纤维细胞增殖及其细胞周期的影响[J]. 中华整形外科杂志, 2009, 26(6): 212-215. DOI: 10.3760/cma.j.issn.1009-4598.2010.03.014 |
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| 作者姓名： | 蔡宏 顾瑛 孙强 曾晶 李世龙 |
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| 作者单位： | 解放军316医院理疗科,100093;解放军总医院激光医学科; |
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| 摘 要： | Objective To investigate the effect of HMME-PDT on the proliferation and cell distribution of hypertrophic scar fibroblast (HSF). Methods HSF were cultured and only 4-6th passages were used in this study. Argyrophilic protein in nucleolar organizer regions( AgNORs) were caculated by I. S% after argyrophilic staining. Flow cytometry was applied to analyze the cell cycle and proliferation index (PI). Results ① I. S% of HSF after HMME-PDT was reduced markedly. ② HMME-PDT inhibited HSF entering S stage from G, stage, cell percentage in S stage was decreased to(11. 2 ± 2. 3 ) % . ③ PI in HMME-PDT group was less than that in control group [( 35.0 ± 3.4) % vs (27. 2 ±3. 1)% , P <0.05]. Conclusions HMME-PDT can inhibite proliferation of HSF, and chang cell distribution.
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| 关 键 词： | 光动力学治疗 成纤维细胞 增殖指数 嗜银蛋白 细胞周期 |
Effect of photodynamic therapy on the proliferation and cell distribution of hypertrophic scar fibroblast |
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| CAI Hong,GU Ying,SUN Qiang,ZENG Jing,LI Shi-long. Effect of photodynamic therapy on the proliferation and cell distribution of hypertrophic scar fibroblast[J]. Chinese journal of plastic surgery, 2009, 26(6): 212-215. DOI: 10.3760/cma.j.issn.1009-4598.2010.03.014 |
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| Authors: | CAI Hong GU Ying SUN Qiang ZENG Jing LI Shi-long |
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| Abstract: | |
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| Keywords: | Photodynamic therapyFibroblastsProliferation indexArgyrophilic protein in nucleolar organizer regionsCell cycle |
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