依那普利联合吲达帕胺治疗糖尿病合并高血压的临床分析

目的 观察依那普利与吲达帕胺联合治疗老年2型糖尿病合并高血压的临床疗效.方法 将99例确诊糖尿病合并高血压的患者随机分为治疗组和对照组,治疗组(50例)用依那普利加吲达帕胺治疗,对照组(49例)单用依那普利治疗.治疗12周比较治疗前后的降压效果、血浆内皮素-1及血清钾、降糖疗效.结果 治疗组的降压效果(82.0%)和降低血浆内皮素-1(75.42±12.16)pg/ml]方面要优于对照组65.3%,(99.09±13.31)pg/ml],但两组在血清钾和降糖方面无显著性差异(P＞0.05).结论 依那普利与吲达帕胺联用可作为治疗糖尿病合并高血压的一种较好的治疗方案.

Clinincal effect of enalapril and indapamide in treatment of patients with diabetic mellitus and hypertension

Objective To study the clinincal effect of enalapril and indapamide in treatment of patients with hypertension and type 2 diabetes mellitus. Metlod Ninty nine patients were randomly divided into two groups:treatment group(enalapril and indapamide) and control group(enalapril),Two groups were all treated for 12weeks. Casual blood pressure,some biochemical parameters,such as ET-1,blood potassuim,blood glucose,were evaluated before and after treatment. Result treatment group (enalapril and indapamide)had better effects than control group (enalapril) in reducing blood pressure and ET-1,while it had no significant in the blood potassuim, blood glucose. Conclusion enalapril and indapamide could be an effective method to care patients with hypertension and type2 diabetes mellitus.