| RhoB-mRNA在喉癌中的表达及其临床意义 |
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| 引用本文： | 侯艳鹏,王铁. RhoB-mRNA在喉癌中的表达及其临床意义[J]. 肿瘤研究与临床, 2009, 21(6): 614-615. DOI: 10.3760/cma.j.issn.1006-9801.2009.09.013 |
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| 作者姓名： | 侯艳鹏 王铁 |
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| 作者单位： | 中国医科大学盛京医院耳鼻咽喉科,沈阳,110003;解放军463医院耳鼻咽喉科; |
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| 摘 要： | Objective To study the expression of RhoB-mRNA,and periphery regions in human laryngeal carcinoma.Methods The expression of RhoB-mRNA were examined by RT-PCR method.Results It was noted that the expression of RhoB-mRNA was positively correlated well with the clinical stages.The expression of RhoB-mRNA in carcinoma with node metastasis group was significantly higher than that without node metastasis.The difference between the two groups was statistically significant(P＜0.05).The expression of RhoB-mRNA in different types and stages of laryngeal carcinoma was significantly different(P＜0.05).The expression of RhoB in laryngeal carcinoma negtive correlation with the stages of laryngeal carcinoma(r=0.557).Conclusion The expression of RhoB plays an inhibitive role in the growth,invasion and local node metastasis of human laryngeal carcinoma.RhoB promote the formation,invasion and lymph node metastasis as oncogenes.It may be valuable as predictors for lymph node metastasis and prognosis.
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| 关 键 词： | 喉肿瘤 逆转录聚合酶链反应 |
Expression of rho proteins RhoB-mRNA in human laryngeal carcinoma |
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