| 新辅助化疗提高食管癌手术R0切除率的研究 |
| |
| 引用本文： | 郑庆锋,冯源,吴楠,姚震旦,刘毅强,王洋,陈晋峰,张力建,杨跃.新辅助化疗提高食管癌手术R0切除率的研究[J].肿瘤研究与临床,2009,22(10):293-296,299. |
| |
| 作者姓名： | 郑庆锋 冯源 吴楠 姚震旦 刘毅强 王洋 陈晋峰 张力建 杨跃 |
| |
| 作者单位： | 北京肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室胸外二科,北京大学临床肿瘤学院,100412;北京肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室病理科,北京大学临床肿瘤学院,100412; |
| |
| 摘 要： | 目的 探讨新辅助化疗提高食管癌手术R0切除率的可能性.方法 30例食管癌患者,其中鳞癌18例,腺癌10例,小细胞癌2例.术前新辅助化疗采用以紫杉醇联合铂类为主的方案,化疗后予以手术治疗.结果 化疗有效率(CR+PR)56.7%(17/30),R0切除率100%,吻合口瘘发生率3.3% (1/30),无死亡病例.结论 新辅助化疗对提高食管癌手术R0切除率具有重要意义,对术后长期生存的影响有待进一步随访观察.
|
| 关 键 词： | 食管肿瘤 新辅助化疗 R0切除率 |
Effect of neoadjuvant chemotherapy on R0 resection rate of esophageal carcinoma |
| |
| ZHENG Qing-feng,FENG Yuan,WU Nan,YAO Zhen-dan,LIU Yi-qiang,WANG Yang,CHEN Jin-feng,ZHANG Li-jian,YANG Yue.Effect of neoadjuvant chemotherapy on R0 resection rate of esophageal carcinoma[J].Cancer Research and Clinic,2009,22(10):293-296,299. |
| |
| Authors: | ZHENG Qing-feng FENG Yuan WU Nan YAO Zhen-dan LIU Yi-qiang WANG Yang CHEN Jin-feng ZHANG Li-jian YANG Yue |
| |
| Abstract: | Objective To investigate the possibility of increasing R0 resection rate in esophageal carcinoma after neoadjuvant chemotherapy. Methods 30 patients underwent operation after neoadjuvant chemotherapy mainly by paclitaxel combined with cis-platinum, including 18 squamous carcinoma cases. 10 adenocarcinoma cases and 2 small cell carcinoma cases.Results In these 30 patients,the overall effective rate of neoadjuvant chemotherapy is 56.7%(17/30)(CR+PR),R0 resection rate is 100%,and the incidence rate of anastomotic leakage is 3.3%(1/30),without perioperative death.Conclusion The neoadjuvant chemotherapv is significant in improving the R0 resection rate in esophageal carcinoma,and the impact of long-term survival after surgery needs further follow-up. |
| |
| Keywords: | Esophageal neoplasmsNeoadjuvant chemotherapyR0 resection rate |
|
|
