系统性红斑狼疮的免疫学发病机制研究进展

系统性红斑狼疮是一种儿童常见的自身免疫性疾病,其免疫学的发病机制复杂.随着免疫学和基因组学的发展,目前的研究已发现其发病与T细胞及B细胞的免疫学异常,尤其是T、B细胞导致的自身免疫耐受被打破,从而产生致病性自身抗体有关,并且系统性红斑狼疮的发病与儿童原发性免疫缺陷密切相关.此外,固有免疫细胞的调节功能异常及其导致的外周免疫耐受的破坏与系统性红斑狼疮的发病及疾病进展有重要联系.

Advance in immunopathogenesis for systemic lupus erythematosus

Systemic lupus erythematosus is a typical autoimmune disease commonly seen in childhood, the immunnopathogenesis of which is complicated. Along with the rapid advances of immunology and molecular biology, all the associated research has found that the onset of systemic lupus erythematosus is associated with dysfunction of T cells and B cells. They focus on the break of the normal autoimmune immunity and the form of malgenic autoantibody. It is also connected with primary immunodeficiency. The dysfunction of inherent immunity contributes to the break of autoimmune and the progression of the disease.