急性冠脉综合征患者血清中TSP-1水平的变化及意义

目的：检测ACS患者血清中TSP-1浓度的变化,探讨其临床意义。方法：78例因胸痛住院患者经CAG和IVUS检查后分为稳定性斑块组（A组）,不稳定性斑块组（B组）,对照组（C组）。采用酶联免疫吸附法对PCI术前后患者血清TSP-1浓度进行连续测定,并对结果进行分析。结果：A、B两组TSP-1浓度在各时间点均高于C组,且B组升高更明显;A、B两组TSP-1均于PCI术后即刻迅速下降,术后2h又缓慢升高,24h出现小的峰值,然后缓慢下降;出院时三组TSP-1浓度无明显差异。结论：TSP-1是诊断ACS的较好的炎性标志物,对ACS的分层有很好的指导作用。

The level of serum TSP-1 in patent with acute coronary syndromes and its significance

Objective： To measure the serum TSP-1 level in patients with ACS and elucidate its clinical significance. Method：78 patients with chest pain were divided into three groups on the basis of CAG and IVUS morphology： group A（stable atheromatous plaques group）; group B（unstable atheromatous plaques group）; group C（negative in CAG）.The TSP-1 levels were measured by ELISA. Rsults：The levels of TSP-1 were higher in group A and B than group C, and more remarkably at erery points in group B. The levels of TSP-1 in group A and B quickly went down to the lowest level after PCI,but began to rise gradually 2h after PCI and reached small peak at 24h. The three groups did not show statistical differences in TSPs-1 level before leaving. Conclusion：The level of TSP-1 was a suitable biomarker for the evaluation of ACS, and correlated with the stability of atheromatous plaques.