重庆市绝经后妇女骨质疏松症的危险因素研究

目的 调查影响重庆市绝经后妇女骨质疏松症发生的危险因素,为骨质疏松的防治提供依据.方法 采取病例-对照的研究方法,对重庆地区绝经后妇女开展标准化问卷凋查,通过非条件Logistic回归模型进行绝经后妇女骨质疏松症的危险因素分析.结果 多因素分析显示,与绝经后妇女骨质疏松症发生呈显著正相关的因素有髋部骨折家族史(OR=8.567,95%CI=3.463～12.620)、低身体质量指数(OR=3.081,95%CI=1.344～5.632)和多产次(OR=2.539,95%CI=1.263～4.175).而常运动(OR=0.276,95%CI=0.152～0.730)、常饮茶(OR=0.354,95%CI=0.209～0.764)和绝经年龄晚(OR=0.621,95%CI=0.327～0.942)与之呈显著负相关.结论 髋部骨折家族史、低身体质量指数和多产次是影响重庆市绝经后妇女骨质疏松症发生的重要危险因素,而经常运动、饮茶以及保持适当的雌激素水平有助于预防绝经后骨质疏松的发生.

Postmenopausal osteoporosis in Chongqing region: a risk factors analysis

Objective To investigate the risk factors of postmenopausal osteoporosis ( PMOP) in Chongqing region, and provide the theoretical basis for osteoporosis prevention and treatment. Methods A hospital-based case-control study was conducted and standardized questionnaire was applied in this project. All patients were informed of the purpose of this study and signed an informed consent form. The protocol and con-sent form were approved by the Ethics Committee of Third Military Medical University. Non-conditional logistic model was used to estimate the association between risk factors and PMOP. Results After adjustment for some potential confounding factors, multivariate non-conditional logistic regression analysis indicated that family histo-ry of hip fracture (OR = 8.567, 95% CI 3.463 to 12.620), lower body mass index (OR =3.081, 95%CI 1. 344 to 5.632) , and parities (OR =2.539, 95% CI 1.263 to 4.175) were significantly positive correlated with the incidence of PMOP. However, frequently exercise (OR = 0. 276, 95% CI 0. 152 to 0. 730) , tea drinking (OR =0.354, 95% CI 0.209 to 0.764) and older at menopause (OR =0.621, 95%CI 0. 327 to 0.942) were significantly negative correlated with it. Conclusion Family history of hip fracture, lower body mass index and higher parities are the risk factors of PMOP in Chongqing region. Besides, frequent exercise, tea drinking and proper endogenous estrogen level are the protective factors.