| MORPHOMETRIC STUDY OF GASTRIC PRECANCEROUS LESIONS: I. QUANTITATIVE DIAGNOSIS OF CELL ATYPISM IN GASTRIC BIOPSY SPECIMENS |
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| 作者姓名： | 赵明朗 王瑞年 邓裕兰 姚季生 苏炳华 萧树东 江绍基 陈德华 |
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| 作者单位： | Department of Pathology，Faculty of Basic Medical Sciences，SSMU，Shanghai，Department of Pathology，Faculty of Basic Medical Sciences，SSMU，Shanghai，Department of Pathology，Faculty of Basic Medical Sciences，SSMU，Shanghai，Department of Pathology，Faculty of Basic Medical Sciences，SSMU，Shanghai，Department of Mathematics，Faculty of Basic Medical Sciences，SSMU，Shanghai，Shanghai Institute of Digestive Disease，Shanghai，Shanghai Institute of Digestive Disease，Shanghai，Shanghai Institute of Non Ferrous Metal，Shanghai |
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| 摘 要： | The cell atypism is one of the important criteria for making diagnosis of precancerous lesions of gastric mucosa, in routine pathological examination, it is evaluated by the degree of atypism of cell nucleus. 5 461 cells in 50 foci of gastric mucosa with intestinal type of lesions (including simple intestinal metaplasia 10; intestinal type dysplasia in different grades: mild 10. moderate 11, severe 9; intestinal type gastric carcinoma 10) have been submitted to morphometric analysis by automatic image analysis system (Quantimet 900). 7 geometric parameters of nucleus were measured by analysis, including: (1) Area; (2) Perimeter; (3) Diameter (2. Area/π1/2; (4) Length; (5) Breadth; (6) Axis ratio (Length / Breadth); (7) Contour (Perimeter~2 / 4π·Area), these parameters represent the size and shape of nucleus. The results of measurements indicated that value of the above mentioned parameters, except the axis ratio and the contour of cell nucleus, all increased in accord with the increase of severity of the atypism in various intestinal type lesions, hence they can be used as objective criteria for quantitative evaluation of gastric precancerous lesions.
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MORPHOMETRIC STUDY OF GASTRIC PRECANCEROUS LESIONS: I. QUANTITATIVE DIAGNOSIS OF CELL ATYPISM IN GASTRIC BIOPSY SPECIMENS |
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| Zhao Minglang Wang Ruinien,Deng Yulan Yao Jisheng.MORPHOMETRIC STUDY OF GASTRIC PRECANCEROUS LESIONS: I. QUANTITATIVE DIAGNOSIS OF CELL ATYPISM IN GASTRIC BIOPSY SPECIMENS[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1988(2). |
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| Authors: | Zhao Minglang Wang Ruinien Deng Yulan Yao Jisheng |
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| Institution: | Zhao Minglang Wang Ruinien Deng Yulan Yao Jisheng Department of Pathology,Faculty of Basic Medical Sciences,SSMU,Shanghai Su Binghua Department of Mathematics,Faculty of Basic Medical Sciences,SSMU,Shanghai Xiao Shudong,Jiang Shaoji Shanghai Institute of Digestive Disease,Shanghai Cheng Dehua Shanghai Institute of Non Ferrous Metal,Shanghai |
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| Abstract: | |
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| Keywords: | gastric mucosa precancerous conditions cells nucleus diagnosis pathology evaluation studies |
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