| 侵袭性恶性黑色素瘤细胞凋亡及PCNA的表达 |
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| 引用本文： | 张锡流,唐农,梁健,何燕玲,朱世龙. 侵袭性恶性黑色素瘤细胞凋亡及PCNA的表达[J]. 广西医科大学学报, 2001, 18(3): 344-346 |
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| 作者姓名： | 张锡流 唐农 梁健 何燕玲 朱世龙 |
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| 作者单位： | 1. 广西中医学院第一附属医院
2. 南宁市第一人民医院 |
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| 摘 要： | 目的：探讨恶性黑色素瘤（恶黑）细胞凋亡，PCNA表达水平关系，找出评价恶黑预后的可靠指标。方法：用原位末端标记法检测细胞凋亡的免疫组化法检测PCNA共20例恶黑石蜡包埋标本。结果：恶黑组织中有细胞凋亡与PCNA阳性表达，阳性率分别为50％和100％,有50％赤组织同时有细胞凋亡与PCNA表达。结论：细胞凋亡及增殖异常与恶黑发生发展有关系，二者的比值可能是判定恶黑预后的又一可靠指标。
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| 关 键 词： | 恶性黑色素瘤 凋亡 增殖细胞核抗原 预后指数 |
| 修稿时间： | 2001-01-10 |
THE EXAMINATION OF APOPTOSIS AND EXPRESSION OF PCNA IN MALIGNANT MELANOMA |
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| Zhang Xiliu,Tang Nong,Liang Jian,et al.. THE EXAMINATION OF APOPTOSIS AND EXPRESSION OF PCNA IN MALIGNANT MELANOMA[J]. Journal of Guangxi Medical University, 2001, 18(3): 344-346 |
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| Authors: | Zhang Xiliu Tang Nong Liang Jian et al. |
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| Abstract: | Objectiv: To study the relationship between apoptosis and proliferating cell nuclear antigen (PCNA) in malignant melanoma, finding the reliable index of judging malignant melanoma. Methods: Using TDT/dUTP nick end labeling and immunohistochemical method, we examined 20 samples of malignant melanoma. Results: There were the expression of apoptosis and PCNA in maligant melanoma,the expression was 50% and 100%.Conclusions:Cell apoptosis and profiferatiom is related to developing of malignant melanoma,the ratio of PCNA and apopsis may be a reliable index to jugde the prognosis of malingant melanoma. |
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| Keywords: | malignant melanoma apoptosis PCNA prognostic factor |
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