| bcl-2基因过表达对小鼠MCAO模型的保护作用 |
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| 引用本文： | 刘艳,程明忠,潘传鼎. bcl-2基因过表达对小鼠MCAO模型的保护作用[J]. 神经损伤与功能重建, 2008, 3(3) |
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| 作者姓名： | 刘艳 程明忠 潘传鼎 |
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| 作者单位： | 武汉市第八医院神经内科,武汉,430010;武汉市第八医院神经内科,武汉,430010;武汉市第八医院神经内科,武汉,430010 |
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| 摘 要： | 目的:探讨bcl-2基因过表达对小鼠MCAO模型的保护作用。方法:野生型小鼠和bcl-2转基因小鼠各8只,分别建立MCAO模型,24 h后测量其脑梗死体积及神经功能缺损评分,并进行比较。结果:转基因小鼠的梗死面积及神经功能评分均显著低于野生型小鼠(P<0.01)。结论:bcl-2基因的过表达能够降低脑梗死的体积并改善小鼠的神经功能。
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| 关 键 词： | bel-2基因 转基因小鼠 脑梗死 MCAO |
Protective Effect of Overexpression of bcl-2 Gene on Mice with Middle Cerebral Artery Occlusion |
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| LIU Yan,CHENG Ming-zhong,PAN Chuan-ding. Protective Effect of Overexpression of bcl-2 Gene on Mice with Middle Cerebral Artery Occlusion[J]. Neural Injury and Functional Reconstruction, 2008, 3(3) |
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| Authors: | LIU Yan CHENG Ming-zhong PAN Chuan-ding |
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| Abstract: | Objective: To explore the protective effect of overexpression of bcl-2 gene on the mice with middle cerebral artery occlusion(MCAO).Methods: The MCAO models were established in 8 wild-type mice and 8 bcl-2 transgenic mice.After 24 h,the infarct volume and the neurological scores were evaluated to compare the differences between those two types.Results: The infarct volume and neurological scores of transgenic mice were apparently lower than those of the wild-type mice.Conclusion: Overexpression of bcl-2 gene in transgenic mice may reduce the infarct volume and improve the neurological function. |
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| Keywords: | bcl-2 gene transgenic mice cerebral infarction MCAO |
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