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| 硒化壳聚糖抗K562细胞作用机制的初步探讨 | |
| 引用本文： | 邓守恒,孙各琴,周有利,邓守明,毛达勇,陈崇宏.硒化壳聚糖抗K562细胞作用机制的初步探讨[J].海峡药学,2005,17(5):29-30. |
| 作者姓名： | 邓守恒 孙各琴 周有利 邓守明 毛达勇 陈崇宏 |
| 作者单位： | 1. 郧阳医学院,附属太和医院检验部,十堰,442000;郧阳医学院,基础医学院,十堰,442000;福建医科大学药学院,福州,350004 2. 郧阳医学院,基础医学院,十堰,442000 3. 郧阳医学院,附属太和医院检验部,十堰,442000 4. 湖北丹江口市第一医院,丹江口,442700 5. 福建医科大学药学院,福州,350004 |
| 摘 要： | 应用分光光度法和放免法观察不同剂量硒化壳聚糖对K562细胞株抗氧化指标及cAMP、cGMP含量的影响,结果发现硒化壳聚糖可明显升高细胞内GSH-PX活力,降低SOD活性和MDA含量,升高cAMP含量,降低cGMP含量,升高cAMP/cGMP比值.降低K562细胞内脂质过氧化水平,升高cAMP/cGMP比值可能是硒化壳聚糖诱导K562细胞凋亡机制之一. |
| 关 键 词： | 硒化壳聚糖 cAMP cGMP GSH-PX SOD MDA |
| 文章编号： | 1006-3765（2005）05-0029-02 |
The Study on the Anti-k562 Cells Mechanism of Selenium Chitosan |
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| DENG Shou-heng,SUN Ge-qing,ZHOU You-li,DENG Shou-ming,MAO Da-yong,Cheng Cong-hong.The Study on the Anti-k562 Cells Mechanism of Selenium Chitosan[J].Strait Pharmaceutical Journal,2005,17(5):29-30. | |
| Authors: | DENG Shou-heng SUN Ge-qing ZHOU You-li DENG Shou-ming MAO Da-yong Cheng Cong-hong |
| Institution: | YunYang Medical College ShiYan 442000,China; 3. The First Hospital of DanJiangKou City DanJiangKou 442700 , China; 4. FuJian Medical University FuZhou 350004; China, |
| Abstract: | The anti-k562 cells mechanism of selenium chitosan was studied by spectrophotometer and radioimmunity methods, we found that selenium could increase the GSH-PX activity,cAMP content and decrease the SOD activity MDA content and cGMP content obviously, this is one of the possible mechanisms which selenium chitosan could induce k562 cells apotosis. |
| Keywords: | Selenium chitosan cAMP cGMP GSH-PX SOD MDA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |