联合检测白细胞计数C-反应蛋白脑利钠肽前体和血浆D-二聚体在慢性阻塞性肺病中的临床应用

目的探讨4项常见检测指标对慢性阻塞性肺病(COPD)的应用价值。方法收集2011年6月至2012年5月COPD及COPD急性加重期(AECOPD)住院患者各60例,同时设同期60名健康体检者为健康对照组,进行白细胞计数(WBC)、C-反应蛋白(CRP)、脑利钠肽前体(pro-BNP)和血浆D-二聚体(D-D)水平检测,对4项指标在诊断慢性阻塞性肺病的价值进行比较和分析。结果与健康对照组比较,COPD患者WBC、D-D、CRP水平差异有统计学意义(P<0.05),pro-BNP水平则无明显变化(P>0.05);与健康对照组及COPD组相比较,AECOPD组CRP水平变化具有统计学意义(P<0.01),其他3项检测指标水平差异均有统计学意义(P<0.05)。结论 WBC、CRP、pro-BNP和D-D的检测,在COPD的发生、发展过程中各具有不同应用价值,是诊断和评估COPD严重程度的有效指标。

Clinical application of combined detection of white blood cell count,C reactive protein,brain natriuretic peptide precursor and D dimmer in patients with chronic obstructive pulmonary disease

Objective To explore the application value of four common indicators in patients with the chronic obstructive pulmonary disease （COPD）. Methods From June 2011 to May 2012 ,COPD and COPD in acute exacerba- tion （AECOPD） in patients with 60 cases respectively were collected, and 60 healthy subjects as control group,Detec tion the content of white blood cell count（WBC）,C reactive protein（CRP）, brain natriuretic peptide precursor （pro- BNP） and plasma D dimer（DD）,comparison and analysis the value of the four indicators in the diagnosis of COPD. Results Compared with the control group,content of the WBC,plasma D-dimer in patients with COPD was statisti- cally significant（P〈0.05）, content of CRP had significant difference （P〈0.01）, content of the pro-BNP had no significant difference （P〉0.05） ;Compared with the control group and the COPD group,content of four indicators in AECOPD group had significant difference （P〈0.05）. Conclusion Detection of WBC,CRP and pro-BNP and plasma DD,each with a different value of application in COPD occurrence,development process,which are effective indicators in diagnosis and assessment of severity of COPD. Four indicators can complement each other and contribute to treatment and prognostic evaluation of COPD.