CA125检测在妇科疾病诊断及鉴别诊断中的作用

目的探讨糖链抗原(CA)125在临床常见妇科疾病诊断中的应用价值。方法采用电化学发光免疫分析法检测821例女性血清CA125水平。结果体检健康者(对照组)血清CA125水平均小于临界值;卵巢癌组为(740.87±1 180.03)U/mL,高于对照组(P<0.05)。宫颈癌组、子宫内膜癌组、子宫肌瘤组、子宫腺肌症组、卵巢囊肿组血清CA125水平高于对照组(P<0.05),子宫内膜息肉组、宫颈炎组与对照组比较差异无统计学意义(P>0.05)。恶性病变中,卵巢癌组与宫颈癌组比较差异有统计学意义(P<0.05),与子宫内膜癌组比较差异有统计学意义(P<0.05);宫颈癌组与子宫内膜癌组比较差异无统计学意义(P>0.05)。良性病变中,子宫肌瘤组与宫颈炎组、子宫内膜息肉组与宫颈炎组比较差异无统计学意义(P>0.05),其余各组比较差异有统计学意义(P<0.05)。恶性病变与良性病变比较,卵巢癌组与子宫腺肌症组比较差异无统计学意义,宫颈癌组与子宫肌瘤组、宫颈炎组比较差异无统计学意义,子宫内膜癌组与卵巢囊肿组、宫颈炎组比较差异无统计学意义(P>0.05),其余各组比较差异有统计学意义(P<0.05)。结论 CA125检测在临床妇科疾病诊断和鉴别诊断中具有一定的价值。

Effect of CA125 detection in the diagnosis and differential diagnosis of gynecological diseases

Objective To investigate the significance of carbohydrate antigen（CA） 125 in the diagnosis of gynecological diseases.Methods Serum CA125 was detected in 821 women by using electro-chemiluminescence immunoassay.Results Serum CA125 levels in healthy subjects（control group） were all less than cut-off value,and in ovarian cancer group was（740.87±1 180.03）U/mL,significantly higher than control group（P0.05）.Serum CA125 levels in cervical cancer group,endometrial cancer group,uterine fibroids group,adenomyosis group,ovarian cyst group were higher than control group（P0.05）.There was no significant differences between endometrial polyps group,cervicitis group and control group（P0.05）.There was significant difference between ovarian cancer group and cervical cancer group（P0.05）,but without difference with endometrial carcinoma group（P0.05）.There was no difference between uterine leiomyoma group and cervicitis group,endometrial polyps group and cervicitis group（P0.05）.There was no significant difference between ovarian cancer group and adenomyosis group,cervical cancer group and uterine myoma group,endometrial carcinoma group and ovarian cysts group,cervicitis group（P0.05）.Conclusion CA125 detection might be with significance for the diagnosis and differential diagnosis of gynecological diseases.