红细胞参数及血清铁蛋白检测在珠蛋白生成障碍性贫血产前诊断中的应用

目的探讨红细胞平均体积(MCV)、红细胞平均血红蛋白含量(MCH)及血清铁蛋白(SF)联合检测在珠蛋白生成障碍性贫血(地中海贫血,简称地贫)产前诊断中的意义。方法随机选择健康孕妇60例(对照组)、缺铁性贫血(IDA)孕妇80例(IDA组)、地贫孕妇120例(地贫组),进行MCV、MCH及SF检测。结果地贫组和IDA组MCV、MCH水平低于健康组(P<0.05),地贫组MCV水平低于IDA组(P<0.05);与对照组比较,IDA组SF水平降低,而地贫组增高(P<0.05)。结论 MCV、MCH及SF是孕妇产前地贫筛查的有效指标。

Application of MCV,MCH and SF for the prenatal diagnosis of thalassemia

Objective To explore the prenatal diagnostic significance of the combined detection of mean corpuscular volume（MCV）,mean corpuscular hemoglobin（MCH） and serum ferritin（SF） for thalassemia.Methods 60 cases of healthy pregnant women（control group）,60 cases of pregnant women with iron deficiency anemia（IDA group） and 120 cases of pregnant women with thalassemia（thalassemia group） were enrolled and detected for MCH,MCV and SF.Results Levels of MCV and MCH in thalassemia group and IDA group were lower than control group（P0.05）.MCV level in thalassemia group was lower than IDA group（P0.05）.Compared with SF level in control group,that in IDA group was lower,but that in thalassemia group was higher（P0.05）.Conclusion MCV,MCH and SF could be effective indicators for the prenatal diagnosis of thalassemia.