常熟地区呼吸病房临床常见革兰阴性菌的分布及耐药性分析

目的分析常熟地区呼吸病房临床常见革兰阴性杆菌分布及耐药性。方法对常熟地区3家市级医院呼吸病房2010年6月至2012年5月分离的革兰阴性杆菌及其耐药性进行回顾性分析。结果分离率前5位分别是肺炎克雷伯菌(35.3%)、铜绿假单胞菌(22.1%)、鲍曼不动杆菌(17.7%)、阴沟肠杆菌(10.1%)和大肠埃希菌(7.6%)。肺炎克雷伯菌和大肠埃希菌超广谱β内酰胺酶阳性率分别为21.4%和58.3%。革兰阴性杆菌对亚胺培南、阿米卡星、哌拉西林/他唑巴坦耐药率较低。结论常熟地区呼吸病房革兰阴性杆菌耐药性较强,必须加强细菌耐药性监测,指导临床合理用药。

Distribution and drug resistance of Gram-negative bacilli isolated from respiratory ward in Changshu area

Objective To investigate the distribution and drug resistance of Gram-negative bacilli isolated from respiratory ward in Changshu area.Methods Gram-negative bacilli isolated from respiratory ward in three Changshu hospitals and their antibiotics resistance were retrospectively analyzed from Jun.2010 to May.2012.Results The most predominant Gram-negative bacteria isolates were K.pneumoniae（35.3%）,P.aeruginosa（22.1%）,A.baumanii（17.7%）,E.cloacae（10.1%） and E.coli（7.6%）.The extended spectrum β-lactamases positive rates of K.pneumoniae and E.coli were 21.4% and 58.3% respectively.There were lower resistant rates in Gram-negative bacteria to Imipenem,Amikacin and Piperacillin/Tazobactam.Conclusion Drug resistance of Gram-negative bacilli isolated from respiratory ward in Changshu area might be serious.Bacterial resistance monitoring should be strengthened,and the data could guide clinical doctors for rational use of antibacterials.