眼科疾病的铜绿假单胞菌的临床分布及耐药性分析

【摘要】 目的 了解眼科医院铜绿假单胞菌的临床分布及其耐药性，为临床医师合理选用抗菌药物提供依据。方法 对2009年1月-2012年12月眼科医院分离的40株铜绿假单胞菌的分布及其耐药性进行回顾性分析。结果 眼科医院铜绿假单胞菌的检出率为5.3%；在革兰氏阴性杆菌中占第一位，主要分离自角膜溃疡物，占67.5%；该菌对氨苄西林/舒巴坦、复方新诺明、头孢噻肟的耐药率达到100%；对阿米卡星、多粘菌素E、美罗培南、哌拉西林/他巴唑坦、妥布霉素的敏感率达到100%。结论 眼科医院分离的铜绿假单胞菌的耐药性低于综合性医院，敏感性较高，但更应加强抗菌药物的管理及耐药性的监测，以减少耐药菌株的出现。

Clinical distribution and drug resistance of Pseudomonas aeruginosa from ophthalmic disease

【Abstract】Objective To master the clinical distribution and drug resistance of Pseudomonas aeruginosa in eye hospital, to direct the doctor reasonably use the antibiotics. Methods A retrospective analysis was performed for the distribution and drug resistance of 40 Pseudomonas aeruginosa strains isolated from Eye hospital during Jan 2009-Dec 2012. Results The detection rate of Pseudomonas aeruginosa was 5.3% in eye hospital; ranking the first in the Gram-negative bacteria, most Pseudomonas aeruginosa isolates were isolated from corneal ulcers(67.5%). This bacterium was high drug resistance rate to ampicillia/sulbactam, CoSMZ and cefotaxime(100%); and well sensitive to amikacin, polymyxin E, meropenem, piperacllin/tazobactam and tobramycin. Conclusions The drug resistance of Pseudomonas aeruginosa in eye hospital is lower than them in general hospital, but it should strengthen the monitoring of drug resistance of Pseudomonas aeruginosa in order to reduce the emergence of multidrug-resistant strains.