沐舒坦治疗新生儿呼吸窘迫综合征的疗效观察

目的　 观察沐舒坦治疗新生儿呼吸窘迫综合征的疗效。 方法 　对 66例符合条件的研究对象进行分层随机分配 ,在上呼吸机的同时 ,治疗组 (34例 )予沐舒坦针剂 (每次 7 5mg/kg) ,对照组 (32例 )则予生理盐水 ,两组输注时间均大于5min ,均每 6h一次 ,连用 7d。实验观察期达 2 8d ,期间观察用药后 2 4、36、48、60、72、84、96h ,各研究对象MAP、PaO2 /FiO2 的变化以及患儿并发症的发生率、两组死亡发生率。 结果 　治疗组与对照组MAP在开始用药后 60h、72h、84h、96h差异有统计学意义 ,P均<0 0 5。两组PaO2 /FiO2 在 60h、72h ,84h ,96h亦差异显著 ,有统计学意义 ,P均 <0 0 5。治疗组及对照组脑室周围 -脑室内出血 (SHE -IVH)发生率分别为 2 9 41%、5 6 2 5 % ,χ2 =4 861,P <0 0 5 ,相对危险度降低率 (RRR) :47 72 % ,需治疗人数 (NNT) :3 7;支气管肺发育不良 (BPD)、气胸、死亡发生率治疗组较对照组均有下降 ,其RRR、NNT均提示有临床意义。 结论 　沐舒坦在用药 60h后能显著改善NRDS的肺换气功能及降低机械通气时的平均气道压力 ,显著减少NRDS患儿中SHE IVH的发生率 ,降低BPD、死亡、气漏的发生率

Evaluation for effect of Mucosolvan on neonatal respiratory distress syndrome

Objective To evaluate the effect of Mucosolvan (Ambroxol) on neonatal respiratory distress syndrome (NRDS).Methods Sixty-six patients of NRDS with ventilator were randomly divided into two groups.Mucosolvan (7^5?mg/kg) was given every six hours in seven continous days in the treatment group (n=34),and continous normal saline as control was used in 32 cases.Mean airway pressure (MAP), PaO-2/FiO-2,incidence of complications and mortality were investigated at 24?h,36?h,48?h,60?h,72?h,96?h after first dose of Mucosolvan.Results There was significant difference between the two groups for MAP and PaO-2/FiO-2 at 60?h,72?h,84?h,96?h, after administration of Mucosolvan (P<0^05).Incidence of subependymal-intraventricular hemorrhage (SEH-IVH) in the treatment group was significantly lower than that of the control (P<0^05).Relative risk reduction (RRR) and number needed to treat (NNT) were 47^72% and 3^7 respectively.Conclusion Mucosolvan can improve pulmonary exchange function of the patients with NRDS,reduce MAP of the patients with ventilation and incidences of SHE-IVH.