不同孕期D-二聚体浓度分析

目的 :探讨产前孕妇血浆D 二聚体水平。方法 :排除D 二聚体增高的相关性疾病 ,将孕妇分成早、中、晚孕三组 ,并设非孕育龄妇女对照组 ,用免疫比浊法对检测对象进行D 二聚体水平分析。结果 :对照组D 二聚体为 0 .2 3 μg/ml± 0 .0 8μg/ml;早、中、晚孕组分别为0 .3 3 μg/ml± 0 .0 9μg/ml、0 .76μg/ml± 0 .2 4μg/ml、1.5 1μg/ml± 1.0 7μg/ml。孕妇各组比较差异显著 (P <0 .0 1) ,与对照组比较 ,D 二聚体均有明显增高 (P <0 .0 1)。结论 :产前孕妇D 二聚体水平普遍高于健康妇女 3～ 4倍。在进行DIC或静脉血栓临床诊断时 ,不能套用健康人正常参考范围 ,否则会造成临床诊断的错误。必须注意对纤维蛋白原 >5 g/L ,D 二聚体正常或略高于正常 ,或显著高于正常的产前孕妇进行动态观察 ,防止DIC发生

Analysis of the Concentration for D-dimer in pregnant women

Objective: To study the concentration of D-dimer in pregnant women.Method: Pregnant women were divided into early、 middle and late period pregnant group. D-dimer was measured by immunoturbidimetric method.Results: The level of D-Dimer in the control group was 0.23 μg/ml±0.08 μg/ml and pregnant groups were 0.33 μg/ml±0.09 μg/ml、0.76 μg/ml±0.24 μg/ml、1.51 μg/ml±1.07 μg/ml.The concentration of D-dimer in pregnant groups was higher than that of the control group(P<0.01).Conclusion: Taking clinical diagnosis,it is necessary to establish itself normal value for pregnant women,because of D-dimer has important clinical significance.