A case of Kleine-Levin syndrome examined with SPECT and neuropsychological testing |
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Authors: | Landtblom A-M Dige N Schwerdt K Säfström P Granérus G |
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Affiliation: | Department of Neuroscience and Locomotion, Link?ping University Hospital, Link?ping, Sweden. Anne-Marie.Landtblom@lio.se |
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Abstract: | A case of Kleine-Levin syndrome with typical periodic hypersomnia and bulimia was diagnosed. On examination with single photo emission tomography (SPECT) (CERETEC) during a relapse period and 2 weeks later there was marked cortical hypoperfusion of the frontal and temporal lobes, especially on the left side as well as in the right parietal lobe. Neuropsychological testing performed 1 week after a relapse showed a reduction in encoding to memory function of verbal learning indicating neocortical damage of the left fronto-temporal region. A follow-up 2 months later after the patient had spontaneously recovered showed only a slight left fronto-temporal disturbance. CT and MRI of the brain were normal although the MRI showed a large and asymmetric mamillary body. Neuropsychological testing 6 years after recovery showed pronounced reduction in short-time verbal and visual memory. Seven years after recovery SPECT demonstrated a normalized frontal perfusion but still a slight hypoperfusion in the left temporal lobe. Our results correlate to autopsy findings in two cases described previously. |
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Keywords: | Kleine–Levin syndrome single photo emission tomography (SPECT) neuropsychological testing |
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