3,5-二碘酪氨酸在大鼠体内的吸收代谢研究

目的 :　研究 3,5-二碘酪氨酸 ( DIT) DIT在动物体内吸收代谢的方式与碘离子的异同 ,为科学补碘提供资料。方法 :　经口灌胃分别给予去甲状腺 Wistar大鼠 DIT或 KI溶液 ,不同时间测血清中 DIT含量变化。结果 :　去甲状腺大鼠和正常大鼠直接摄入 DIT后 ,血清中 DIT含量明显增高 ,至 3h达最高值 ,6h后基本恢复正常 ,而摄入 KI者 ,血清 DIT含量几乎不随时间变化。结论 :　DIT是以分子形式吸收参加代谢的 ,而不是先转化成 I-形式后再吸收。

STUDY ON THE ABSORPTION AND METABOLISM OF 3,5-DIIODINE-TYROSINE IN RAT

Objective: To study the absorption and metabolism of DIT and I in rat.Method:DIT and KI solution were given intragastrically to different groups of rats. The DIT content of serum was determined in different times. Results: The DIT content of serum was enhanced significantly in the thyroidectomized and normal rats, which were both given DIT. The DIT content of serum in animals given KI didnt change. Conclusion: DIT was absorbed in molecular form, not in form of I -.