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Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples
Authors:Peter Saetre  Maria Vares  Thomas Werge  Ole A. Andreassen  Tadao Arinami  Hiroki Ishiguro  Shinichiro Nanko  Ene Choo Tan  Doug Hyun Han  Joshua L. Roffman  Jan‐Willem Muntjewerff  Pawel P. Jagodzinski  Bartosz Kempisty  Joanna Hauser  Elisabet Vilella  Elitza Betcheva  Yusuke Nakamura  Björn Regland  Ingrid Agartz  Håkan Hall  Lars Terenius  Erik G. Jönsson
Affiliation:1. Department of Clinical Neuroscience, HUBIN Project, Karolinska Institutet and Hospital, Stockholm, Sweden;2. Research Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark;3. Institute of Psychiatry, University of Oslo, Oslo, Norway;4. Department Psychiatry, Oslo University Hospital, Oslo, Norway;5. Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan;6. Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan;7. KK Research Centre, KK Women's and Children's Hospital, Singapore, Singapore;8. Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;9. Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea;10. Schizophrenia Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;11. Department of Psychiatry, University Medical Centre St Radboud, Nijmegen, The Netherlands;12. Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland;13. Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland;14. Psychiatry University Hospital Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, Spain;15. Department of Medical Genetics, Medical University, Sofia, Bulgaria;16. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;17. Institute of Clinical Neuroscience, G?teborg University, G?teborg, Sweden;18. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway;19. Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
Abstract:Methylenetetrahydrofolate reductase (MTHFR) is involved in the one‐carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes two common polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) which both alter enzyme activity. The T‐allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia. In the present study we examined the association between the MTHFR C677T and A1298C polymorphisms and age at onset of schizophrenia in twelve samples consisting of 3,213 unrelated schizophrenia patients, including the original Scandinavian sample. There was no consistent relationship between MTHFR C677T, A1298C or combined 677T/1298C carriers and age of onset in schizophrenia when the results of each study were combined using meta‐analysis. The present results suggest that the investigated MTHFR polymorphisms do not influence age of onset in schizophrenia. © 2011 Wiley‐Liss, Inc.
Keywords:methylenetetrahydrofolate reductase gene (MTHFR)  schizophrenia  age of onset
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