Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21 |
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| Authors: | Per Hoffmann André Kleensang Kerstin U. Ludwig Tiemo Grimm Nina Neuhoff Maike Preis Darina Roeske Andreas Warnke Peter Propping Helmut Remschmidt Markus M. Nöthen Andreas Ziegler Gerd Schulte‐Körne |
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| Affiliation: | 1. Institute of Human Genetics, University of Bonn, Bonn, Germany;2. Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany;3. Institute of Medical Biometry and Statistics, University at Lübeck, Lübeck, Germany;4. European Centre for the Validation of Alternative Methods (ECVAM), Institute for Health and Consumer Protection, DG Joint Research Centre, European Commission, Ispra, Italy;5. Institute of Human Genetics, University of Würzburg, Würzburg, Germany;6. Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, University of Munich, Munich, Germany;7. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany;8. Max‐Planck Institute of Psychiatry, Munich, Germany;9. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany |
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| Abstract: | In a genome‐wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single‐proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome‐wide significant LOD score of 5.87 (P = 1.00 × 10?7) and the implicated 6p‐risk region spans around 10 Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | dyslexia genome scan linkage DYX2 DCDC2 KIAA0319 |
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