Hypothalamic metallic deposition and the production of experimental obesity |
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| Authors: | Paul U Dubuc Robert W Reynolds |
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| Institution: | Department of Metabolism and Endocrinology, City of Hope National Medical Center Duarte, California 91010, USA;Department of Psychology, University of California, Santa Barbara Santa Barbara, California 93106, USA |
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| Abstract: | The effectiveness of the deposition of metallic ions in the medial hypothalamus in producing experimental obesity in rats was investigated. Both the direct deposition to the hypothalamus of Fe+++ (as FeCl3 · 6H2O) or Cu++ (as CuCl2 · 2H2O) via bilateral stainless steel cannulae or via anodal electrolysis with stainless steel or copper electrodes resulted in similar significant increases in daily weight gain and the development of obesity. NaCl deposition via cannulae, sham lesions, and empty cannulae insertion were all ineffective in altering body weight. These results suggest that: (a) the electrical events associated with anodal direct current lesions using stainless steel or copper electrodes are secondary to the deposition of metallic ions in the production of experimental obesity; and, (b) the tissue destruction in the ventromedial hypothalamic region coupled with the presence of heavy metal ions apparently ‘add’ to produce a very high probability of the development of experimental obesity. |
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| Keywords: | Experimental obesity Ventromedial hypothalamus Electrolytic lesions Irritative focus Hyperphagia Satiety center Body weight |
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