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| MMP2、uPA在腺样囊性癌中表达的临床病理研究 | |
| 引用本文： | 杨美兰,朱红,曾亮,邓亚平,刘志红,. MMP2、uPA在腺样囊性癌中表达的临床病理研究[J]. 中国医学工程, 2007, 15(5): 416-418 |
| 作者姓名： | 杨美兰 朱红 曾亮 邓亚平 刘志红 |
| 作者单位： | 1. 怀化医学高等专科学校附属医院暨怀化市第三人民医院病理科,湖南怀化418000 2. 中南大学湘雅医院肿瘤科,湖南长沙410008 3. 湖南省肿瘤医院病理科,湖南长沙410013 |
| 摘 要： | 目的观察MMP2、uPA在腺样囊性癌中的表达及在肿瘤复发中的意义。方法收集80例腺样囊性癌病例,根据随访资料分为复发组和非复发组,用免疫组织化学SP法分别检测MMP2、uPA在腺样囊性癌组织中的表达。结果MMP2、uPA在腺样囊性癌组织中的阳性表达率分别为42.5%(34/80)、56.25%(45/80);MMP2、uPA表达在复发组和非复发组间均有差异,有统计学意义(P<0.05);MMP2、uPA表达相关性有统计学意义。结论MMP2、uPA表达与腺样囊性癌的复发有关。 |
| 关 键 词： | 腺样囊性癌 基质金属蛋白酶2 尿激酶型纤溶酶原激活物 复发 |
| 文章编号： | 1672-2019（2007）05-0416-03 |
| 修稿时间： | 2007-02-24 |
Clinopathological study on the expression of MMP2 and uPA in adenoid cystic carcinoma tissues |
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| YANG Mei-lan,ZHU Hong,ZENG Liang,DENG Ya-ping,LIU Zhi-hong. Clinopathological study on the expression of MMP2 and uPA in adenoid cystic carcinoma tissues[J]. China Medical Engineering, 2007, 15(5): 416-418 | |
| Authors: | YANG Mei-lan ZHU Hong ZENG Liang DENG Ya-ping LIU Zhi-hong |
| Abstract: | Objective To observe matrix metalloproteinases2(MMP2)and Urokinase-type plasminogen activator(uPA)expression,and to analyze the relationship to recurrence.Method MMP2 and uPA expression were assayed respectively in 80 adenoid cystic carcinoma(ACC)tissues including recurrence group and non-recurrence group by immunohistochemical method.Results The positive expression rates of MMP2 and uPA in ACC were 42.5%(34/80)and 56.25%(45/80);The positive expression rates of MMP2 and uPA in recurrence group were in non-recurrence group(P <0.05);Significant correlation existed between MMP2 and uPA.Conclusion MMP2 and uPA were related to recurrence of ACC. |
| Keywords: | adenoid cystic carcinoma matrix metalloproteinases 2 urokinase-type plasminogen activator recurrence |
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