sema3c在胰腺癌组织中的表达及其临床意义

目的:探讨sema3c在胰腺癌组织中的表达及其临床意义.方法:采用免疫组织化学法对122例胰腺癌组织及癌旁组织进行sema3c表达的检测,分析sema3c表达与胰腺癌患者临床病理特征和预后的关系.结果:在122例胰腺癌组织中,共有86例表现出阳性表达,阳性率为70.5％(86/122);在癌旁组织中共有18例表现出阳性...

Expression of sema3c in pancreatic cancer tissues and its clinical significance

Objective:To study the expression of sema3c in pancreatic cancer tissues and its clinical significance.Methods:Immunohistochemical method was used to detect the expression of sema3c in 122 cases of pancreatic cancer tissues and adjacent tissues,and the relationship between sema3c expression and clinicopathological characteristics and prognosis of patients with pancreatic cancer was analyzed.Results:Among 122 pancreatic cancer tissues,86 cases showed positive expression,and the positive rate was 70.5% (86/122).A total of 18 cases were positive in the adjacent tissues,and the positive rate was 14.8% (18/122).There was significant difference between the two groups (P=0.000).The expression of sema3c was related to the TNM stage and the presence or absence of lymph node metastasis of pancreatic cancer (all P＜0.05).It was not related to the patient's gender,age,tumor size,and degree of tumor differentiation (all P＞0.05).Follow-up was performed on 122 patients with pancreatic cancer.The median survival of patients with sema3c negative expression was 27(9,45) months,and the median survival of patients with sema3c positive expression was 10(7,31) months.The five-year survival rate of patients with sema3c positive expression was significantly lower than that of patients with sema3c negative expression (P=0.011).The clinical and pathological parameters of 122 patients with pancreatic cancer were included in univariate COX regression analysis.The results showed that tumor TNM stage,degree of differentiation,the presence or absence of lymph node metastasis and sema3c expression were correlated with prognosis (all P＜0.05).The above factors affecting prognosis were included in multivariate regression analysis.The results showed that tumor TNM stage,degree of differentiation,the presence or absence of lymph node metastasis and sema3c expression can be used as independent prognostic factors for overall survival of patients with pancreatic cancer (all P＜0.05).Conclusion:sema3c may be one of the targets for the treatment of pancreatic cancer,and it may have obvious value for judging the prognosis.