多灶甲状腺乳头状癌的临床特点分析

目的:比较多灶甲状腺乳头状癌（MPTC）与单灶甲状腺乳头状癌（SPTC）的临床和病理特点。方法:回顾性分析我院经手术治疗且病理证实的43例MPTC和78例SPTC患者的临床及病理资料。结果:两组间性别、年龄分段、合并桥本甲状腺炎及结节性甲状腺肿、微小癌比例、病理分期，无统计学差异（P＞0.05）；MPTC组年龄、腺外浸润发生率、淋巴结转移率、手术并发症发生率及术后低钙发生率均高于SPTC组，差异有统计学意义（P＜0.05）。结论:MPTC年龄多较大，更易发生腺外浸润和淋巴结转移，建议行全甲状腺切除+患侧颈中央区淋巴结清扫。

Clinical characteristics of multifocal papillary thyroid carcinoma

Objective:To compare the clinical and pathological features of multifocal papillary thyroid carcinoma (MPTC) and solitary papillary thyroid carcinoma (SPTC).Methods:The clinical and pathological data of 43 patients with MPTC and 78 patients with SPTC who were surgically treated and pathologically confirmed in our hospital were retrospectively analysed.Results:There were no significant differences between the two groups in gender,age,Hashimoto's thyroiditis and nodular goiter,proportion of microcarcinoma,and pathological stage (P＞0.05).Age,extra-glandular infiltration rate,lymph node metastasis rate,surgical complication rate and postoperative hypocalcemia rate in MPTC group were higher than SPTC group,and the difference was statistically significant (P＜0.05).Conclusion:MPTC is older and more prone to extra-glandular infiltration and lymph node metastasis.Total thyroidectomy and central lymph node dissection are recommended.