健康体检者血浆黏度异常相关影响因素及效应关系探讨

目的　探讨血浆黏度（PV）异常的影响因素，为慢性疾病的早期预防提供参考。方法　在健康体检者资料库中选取PV异常者（异常组）930例，匹配年龄、性别、工种后按正常组∶异常组=3∶1选取PV正常者（正常组）2 790例。通过单因素分析、条件Logistic回归分析筛选PV异常的相关因素。对应分析展示不同程度的PV与相关因素的聚集性。中介效应验证PV在代谢指标异常和肾脏功能异常之间的介导作用。结果　与正常组比较，异常组血肌酐（SCr）、血尿酸（UA）、空腹血糖（FPG）、总胆固醇（TC）及三酰甘油（TG）水平升高，而估算肾小球滤过率（eGFR）降低（P＜0.01）。条件Logistic回归分析显示，较高的SCr、TC和TG是PV异常的危险因素（P＜0.05）。对应分析显示，在PV逐渐升高的过程中，TC最先出现异常，TG次之，而SCr的升高最后出现。中介效应显示，在肾功能的变化中，PV对TC和TG的中介效应分别为44.0%和47.1%。结论　PV与SCr、TC和TG呈正向关联关系；TC、TG对肾功能损伤有直接影响，PV在TC、TG与肾功能损伤之间起到了一定的中介作用。

Study on related factors and effect relationship of abnormal plasma viscosity in health check-up participants

Objective　To investigate the influencing factors of abnormal plasma viscosity (PV) and provide reference for the early prevention of chronic diseases. Methods　A total of 930 participants with abnormal PV (the abnormal group) were selected from the database of health examinees. After matching age, gender and type of work, 2 790 participants with normal PV (the normal group) were selected according to the ratio of normal group to abnormal group = 3∶1. Univariate analysis and conditional Logistic regression analysis were used to screen the related factors of abnormal PV. The aggregation of different levels of PV and related factors were demonstrated by correspondence analysed. The mediating effect verified the mediating role of PV between abnormal metabolic indicators and abnormal renal function. Results　The serum levels of creatinine (SCr), uric acid (UA), fasting plasma glucose (FPG), total cholesterol (TC) and triglyceride (TG) were significantly higher in the abnormal group than those in the normal group, while the estimated glomerular filtration rate (eGFR) was lower (P＜0.01). Conditional Logistic regression analysis showed that the higher SCr, TC and TG were risk factors for abnormal PV (P＜0.05). Correspondence analysis showed that during the gradual increase of PV, TC was the first to appear abnormal, followed by TG, and the increase of SCr appeared last. The mediating effect showed that in the changes of renal function, the mediating effects of PV on TC and TG were 44.0% and 47.1%, respectively. Conclusion　PV shows a positive correlation with SCr, TC and TG. TC and TG have a direct impacts on renal impairment, and PV plays a certain mediating role in TC, TG and renal function injury.