甲型流感病毒血凝素研究进展

甲型流感病毒是一种人兽共患病的病原体,它可以引起季节性流感和人感染动物源性流感等多种疾病,具有传染性强、变异率高、危害性大等特点,一直以来都是监测及研究的重点对象.血凝素作为病毒表面的重要糖蛋白之一,在病毒的宿主嗜性、生命周期、变异进化,防控工作的监测监查以及相关抗流感药物的研发等方面地位突出.本文从形态结构、功能作用...

Research progress in influenza A virus hemagglutinin

Influenza A virus is a pathogen causing zoonotic diseases, such as seasonal influenza and human infection with animal-derived influenza virus. The virus has characteristics including strong infectivity, a high mutation rate and high potential for harm. It has long been a focus of personnel monitoring and research. Hemagglutinin, an important glycoprotein on the surface of the virus, plays a prominent role in the influenza virus life cycle, variation and evolution, and host tropism, as well as in the monitoring and inspection of prevention and control measures and the development of anti-influenza drugs. Therefore, this paper reviews the research progress in hemagglutinin in recent years according to four aspects—morphological structure, function, variation and evolution, and drugs—to improve knowledge and understanding of hemagglutinin by researchers and the public and provide a reference for prevention and treatment.