| EIF5A2在人肝细胞癌中的表达及其与术后生存期的关系 |
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| 引用本文： | 杨茜,叶冬雪,马晏然,胡小媛,李宏,周璇,项锋钢. EIF5A2在人肝细胞癌中的表达及其与术后生存期的关系[J]. 肿瘤防治研究, 2021, 48(6): 617-624. DOI: 10.3971/j.issn.1000-8578.2021.20.1437 |
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| 作者姓名： | 杨茜 叶冬雪 马晏然 胡小媛 李宏 周璇 项锋钢 |
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| 作者单位： | 1. 266021 青岛，青岛大学基础医学院病理系；2. 266003 青岛，青岛大学附属医院病理科 |
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| 基金项目： | 国家自然科学基金（81502388） |
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| 摘 要： | 目的 检测真核翻译起始因子5A2(EIF5A2)在肝细胞癌(HCC)中的表达,探讨其与临床病理特征及预后的关系.方法 qRT-PCR和Western blot法分别检测12对新鲜HCC及癌旁非瘤组织中EIF5A2 mRNA和蛋白水平的表达;免疫组织化学检测284对HCC及癌旁非瘤组织中EIF5A2的表达水平,并分析其与...
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| 关 键 词： | EIF5A2 肝细胞癌 免疫组织化学 预后 |
| 收稿时间： | 2020-12-09 |
EIF5A2 Expression in Hepatocellular Carcinoma and Its Relation with Postoperative Survival |
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| YANG Qian,YE Dongxue,MA Yanran,HU Xiaoyuan,LI Hong,ZHOU Xuan,XIANG Fenggang. EIF5A2 Expression in Hepatocellular Carcinoma and Its Relation with Postoperative Survival[J]. Cancer Research on Prevention and Treatment, 2021, 48(6): 617-624. DOI: 10.3971/j.issn.1000-8578.2021.20.1437 |
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| Authors: | YANG Qian YE Dongxue MA Yanran HU Xiaoyuan LI Hong ZHOU Xuan XIANG Fenggang |
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| Affiliation: | 1. Department of Pathology, School of Basic Medicine, Qingdao University, Qingdao 266021, China; 2. Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China |
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| Abstract: | Objective To detect the expression of EIF5A2 in hepatocellular carcinoma(HCC) and to explore its relation with clinicopathological characters and prognosis of HCC patients. Methods The expression of EIF5A2 mRNA and protein in 12 pairs of fresh HCC and corresponding non-tumor tissues adjacent to the cancer was examined by qRT-PCR and Western blot. The expression level of EIF5A2 in 284 pairs of HCC and adjacent non-tumor tissues was detected by IHC staining. Then we analyzed between EIF5A2 expression and clinical pathological parameters and prognosis of HCC patients. Results The relative expression levels of EIF5A2 mRNA and protein in fresh HCC tissues were significantly higher than those in the corresponding adjacent non-tumor tissues (t=5.305, P=0.0003; t=10.120, P<0.001); EIF5A2 expression in 284 HCC tissues was significantly higher than that in the corresponding adjacent non-tumor tissues (z=-12.186, P<0.001). The expression of EIF5A2 was significantly correlated with tumor size (χ2=13.079, P<0.001), tumor multiplicity (χ2=4.589, P=0.032) and differentiation degree (χ2=4.844, P=0.028). The 3- and 5-year overall survival time and disease-free survival time of the patients with high expression of EIF5A2 were significantly shorter than those with low expression of EIF5A2 (P<0.001). EIF5A2 was an independent prognostic factor affecting the 3- and 5-year overall survival time and disease-free survival time of HCC patients (P<0.05). Conclusion The up-regulation of EIF5A2 expression may be related with the occurrence and development of hepatocellular carcinoma. The high expression of EIF5A2 is an independent influence factor for poor prognosis and EIF5A2 can be used as a potential molecular marker for predicting the prognosis of HCC patients. |
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| Keywords: | EIF5A2 Hepatocellular carcinoma Immunohistochemistry Prognosis |
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