吲哚菁绿荧光联合纳米碳示踪检测在甲状腺乳头状癌前哨淋巴结定位中的应用

目的 探索吲哚菁绿荧光联合纳米碳示踪检测在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)前哨淋巴结(sentinel lymph node,SLN)定位中的应用价值.方法 选择2017年7月-2018年7月在宁波市鄞州人民医院接受手术治疗的PTC患者90例,术中使用吲哚菁绿荧光联合纳米...

Application value of indocyanine green fluorescence combined with carbon nanotracer in sentinel lymph node localization of papillary thyroid cancer

  Objective  To explore the application value of indocyanine green fluorescence combined with carbon nanotracer in sentinel lymph node (SLN) localization of papillary thyroid cancer (PTC).  Methods  Ninety patients with PTC who underwent surgery in our hospital from July 2017 to July 2018 were enrolled. Sixty patients with indocyanine green fluorescence combined with carbon nanotracer as observation group, and 30 patients with carbon nanotracer as control group. The location and number of SLNs in both groups were recorded, followed by cervical lymph node dissection. Surgically resected sentinel lymph nodes and other dissected lymph nodes were frozen for pathological examination, relevant indicators were compared between the two groups.  Results  There was no significant difference in sex, tumor size, multifocal and TNM staging, age, operation time, intraoperative bleeding volume and sentinel lymph node resection time between the two groups (all P>0.05). The detection rate, accuracy and sensitivity of SLN in the observation group were significantly higher than those in the control group, and the false negative rate was significantly lower than that in the control group (all P < .05). There was no significant difference in the average number of SLN detected between the two groups (t=0.569, P>0.05). The influence of clinicopathological parameters on sentinel lymph node detection was analyzed, it was found that the patient's gender, age, tumor size, multifocal, TNM staging and other pathological parameters had no significant effect on SLN detection rate and accuracy (all P>0.05).  Conclusion  Indocyanine green fluorescence combined with carbon nanotracer has good visibility as a lymph node tracer. The detection rate, accuracy and sensitivity of SLN is significantly higher than that of single-use nano-carbon. It has high application value in SLN biopsy of thyroid papillary carcinoma.