网织红细胞参数及未成熟粒细胞相对值在不良妊娠结局中的预测价值

目的 探讨网织红细胞参数及未成熟粒细胞对孕妇不良妊娠结局的预测价值.方法 选取100例非妊娠妇女、300例正常妊娠妇女和201例不良妊娠妇女分成3组.采用日本SysmexXN-9000全自动血细胞分析仪检测网织红细胞百分比(reticulocyte percentage,Ret％)、未成熟网织红细胞指数(immatur...

Predictive value of reticulocyte parameters and relative value of immature granulocytes in adverse pregnancy outcome

  Objective  To investigate the predictive value of reticulocyte parameters and immature granulocytes in pregnant women with adverse pregnancy outcomes.  Methods  A total of 100 non-pregnant women, 300 normal pregnant women and 201 unhealthy pregnant women were divided into three groups. The reticulocyte percentage (Ret%), immature reticulocyte index (IRF), reticulocyte haemoglobin (Ret-He), and relative value (%IG) of immature granulocytes and haemoglobin (Hb) were detected by XN-9000 automatic haematology analyser (Sysmex, Japan). The ROC curve was used to explore the predictive value of reticulocyte parameters and relative value of immature granulocytes for adverse pregnancy outcomes of pregnant women.  Results  Compared with the non-pregnancy group, the unhealthy pregnant women group had significantly reduced Hb and Ret-He and increased IRF (P < 0.05), whilst the normal pregnancy group had significantly reduced Hb and significantly increased Ret%, IRF and %IG (P < 0.05). Compared with the normal pregnancy group, the unhealthy pregnant women group had significantly reduced Hb, Ret%, IRF, Ret-He and %IG (P < 0.05). The areas under the ROC curve of Ret%, IRF, Ret-He and %IG were 0.611, 0.619, 0.727 and 0.821, respectively. The best predicted cut-off values were 1.695, 14.100, 32.450 and 1.350. The sensitivity values were 0.814, 0.833, 0.502 and 0.671, whereas the specificity values were 0.375, 0.667, 0.875 and 0.896.  Conclusion  The Ret%, IRF, Ret-He and %IG are related to the occurrence of adverse pregnancy outcomes. The %IG predicts the occurrence of adverse pregnancy outcomes with the greatest specificity, whilst IRF has the highest sensitivity. Reticulocyte parameters combined with the detection of the relative value of immature granulocytes have certain value in predicting the adverse pregnancy outcomes of pregnant women.