舒芬太尼与瑞芬太尼联合应用对乳腺癌根治术患者麻醉效果和应激反应的影响

目的:探讨舒芬太尼和瑞芬太尼联合应用对乳腺癌根治术患者麻醉效果及应激反应的影响.方法:选择2017年01月-2019年01月我院乳腺癌根治术患者80例,随机分为实验组(舒芬太尼和瑞芬太尼联合用药)、对照组(单用瑞芬太尼)两组,每组40例.观察两组患者在麻醉前0 min(T1)、气管插管前即刻(T2)、插管后1 min(...

Effects of sufentanil combined with remifentanil on the effect of anesthesia and stress response in patients undergoing radical mastectomy

Objective:To investigate the effect of combined use of sufentanil and remifentanil on perioperative stress response in patients undergoing radical mastectomy.Methods:Eighty cases of patients undergoing radical mastectomy were randomly divided into the experimental group (sufentanil and remifentanil combination) and the control group (remifentanil alone),with 40 cases in each group.The heart rate (HR),mean arterial pressure (MAP) and pulse oxygen saturation (SPO2) of patients in the two groups before anesthesia 0 min (T1),before endotracheal intubation (T2),1 min after intubation (T3),1 min after extubation (T4),and 5 min after extubation (T5) were recorded.VAS score at 6 h(T6),12 h(T7) and 24 h(T8) after extubation,agitation score (RS) and alertness/sedation score (OAA/S) were evaluated.Meanwhile,the levels of norepinephrine (NE) and epinephrine (E) at T1,T3,T4,T6,T7 and T8 were detected.Results:The levels of HR and MAP in the two groups were lower at T2 than at T1 (P＜0.05).At T3-T5,the levels of HR and MAP in the experimental group were significantly lower than those in the control group (P＜0.05).The levels of NE and E in both groups were higher at T3 and T4 than at T1 (P＜0.05),lower at T7 and T8 than at T1 (P＜0.05).At the time points of T3,T4,T6,T7 and T8,the levels of NE and E in the experimental group were significantly lower than those in the control group (P＜0.05).RS,OAA/S and VAS scores in the experimental group were significantly lower than those in the control group (P＜0.05).No significant difference was observed in SPO2 at each time point between the two groups (P＞0.05).Conclusion:The combined use of sufentanil and remifentanil can better reduce the perioperative stress response of patients undergoing radical mastectomy compared with the single use of remifentanil for anesthesia.