代谢综合征患者糖脂代谢和血尿酸水平对血清甲胎蛋白浓度的影响

目的 研究代谢综合征(MS)患者的代谢参数与血清甲胎蛋白(AFP)浓度之间的关系,明确代谢参数对AFP的影响,为MS患者肿瘤防治提供参考.方法 收集2017年6月-2020年6月在重庆大学附属中心医院住院的415例MS患者和参与体检的227例非MS人群的一般资料,测量腹围、收缩压、舒张压、AFP、空腹血糖(FBS)、糖...

Effects of glycolipid metabolism and blood uric acid level on serum alpha-fetoprotein concentration in patients with metabolic syndrome

  Objective  To study the relationship between metabolic parameters and serum alpha-fetoprotein (AFP) of patients with metabolic syndrome (MS) and to clarify the influence of metabolic parameters on AFP, in order to provide reference for MS patients in cancer prevention and treatment.  Methods  General information of 415 MS patients and 227 non-MS people who participated in physical examination at Central Hospital of Chongqing University from June 2017 to June 2020 were collected. Abdominal circumference, systolic blood pressure, diastolic blood pressure, AFP, fasting blood glucose (FBS), glycated hemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), urea nitrogen (BUN), serum creatinine (Cr), blood uric acid (UA), β2-microglobulin and cystatin-C were measured. Differences in the above parameters between patients with MS and non-MS were compared. The parameters of different AFP concentrations in MS patients were compared and the relationship between AFP and parameters in patients with MS were analyzed.  Results  The serum AFP concentration in the MS group was significantly higher than that in the non-MS group (P < 0.001). When the FBS, HbA1c, TC, LDL, and UA of MS patients were high, the serum AFP concentration matched corresponds to the high concentration level (P < 0.001), showing a significant positive correlation (P < 0.001). FBS (β'=0.460, P < 0.001), HbA1c (β'=0.212, P < 0.001), UA (β'=0.348, P < 0.001) were independently correlated with serum AFP concentrations.  Conclusion  Glycolipid metabolism and blood uric acid levels in MS patients may affect serum AFP concentration, and this influence was more significant when glucose metabolism and blood uric acid were abnormal.