| 结核分枝杆菌PE/PPE蛋白家族生物学研究进展 |
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| 引用本文： | 王璞,蔡玉荣,张刚,孔云逸,穆爱娟,李勇. 结核分枝杆菌PE/PPE蛋白家族生物学研究进展[J]. 中国人兽共患病杂志, 2021, 37(10): 937-944. DOI: 10.3969/j.issn.1002-2694.2021.00.136 |
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| 作者姓名： | 王璞 蔡玉荣 张刚 孔云逸 穆爱娟 李勇 |
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| 作者单位： | 1.宁夏大学西部生物资源保护与利用教育部重点实验室,银川 750021;2.宁夏大学生命科学学院,银川 750021;3.贺兰县农业农村局农业综合执法大队,贺兰 750200 |
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| 基金项目： | 宁夏回族自治区重点研发计划项目资助课题(No.2017BN04); 国家自然科学基金(No.31560694) |
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| 摘 要： | 结核分枝杆菌(Mycobacterium tuberculosis,MTB)是引起结核病的病原体,也是单一感染微生物导致死亡的最重要原因。在MTB基因组上有一类特殊的蛋白家族——PE/PPE蛋白家族,该蛋白家族对细菌毒力、抗原变异、宿主细胞命运等至关重要,且在特异性诊断试剂和疫苗研制中具有广阔的应用前景。本文将从PE/PPE蛋白家族的结构特征、生物学功能、及其对宿主免疫反应调控等方面的近年来研究进展作一综述。
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| 关 键 词： | 结核分枝杆菌 PE/PPE Th1 巨噬细胞 |
| 收稿时间： | 2021-03-22 |
Research progress in the biology of PE/PPE protein family of Mycobacterium tuberculosis |
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| WANG Pu,CAI Yu-rong,ZHANG Gang,KONG Yun-yi,MU Ai-juan,LI Yong. Research progress in the biology of PE/PPE protein family of Mycobacterium tuberculosis[J]. Chinese Journal of Zoonoses, 2021, 37(10): 937-944. DOI: 10.3969/j.issn.1002-2694.2021.00.136 |
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| Authors: | WANG Pu CAI Yu-rong ZHANG Gang KONG Yun-yi MU Ai-juan LI Yong |
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| Affiliation: | 1. Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western, Yinchuan 750021, China;2. School of Life Science, Ningxia University, Yinchuan 750021, China;3. Agriculture and Rural Affairs Bureau of Helan County Agricultural Comprehensive Law Enforcement Brigade , Helan 750200, China |
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| Abstract: | Mycobacterium tuberculosis (MTB) is the pathogen that causes tuberculosis, and it is also the most important cause of death from single microbial infection. There is a special protein family in the MTB genome-the PE/PPE protein family. This protein family is critical to bacterial virulence, antigenic variation, host cell fate, etc., and has a broad application prospects in the development of specific diagnostic reagents and vaccines. In this paper, the structural characteristics, biological functions and the regulation of host immune response of PE/PPE protein family are reviewed. |
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| Keywords: | Mycobacterium tuberculosis PE/PPE Th1 macrophage |
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