空腹甘油三酯血糖指数与原发性高血压患者动脉硬化的相关性研究

  目的  研究不同空腹甘油三酯血糖(triglyceride glucose index，TyG)指数原发性高血压患者的动态血压及臂踝脉搏波速度(brachia-ankle pulse wave velocity，ba-PWV)情况，探讨TyG指数与ba-PWV的相关性。  方法  本研究为回顾性研究，连续选取2014年8月—2015年12月住院的原发性高血压患者466例。根据TyG指数分为低、中、高3组，比较不同组间的动态血压及ba-PWV差异，并利用多元线性回归模型分析ba-PWV的影响因素。  结果  随着TyG指数组别级数越大，患者中高脂血症及糖尿病的比率越高，BMI平均值越大，总胆固醇、甘油三酯、低密度脂蛋白胆固醇、尿酸及空腹血糖水平也逐渐升高。TyG指数高组24小时平均收缩压及舒张压显著高于低组(132.3±14.8)mm Hg vs. (127.0±14.9)mm Hg, P=0.003；(81.1±11.8)mm Hg vs. (77.8±11.5)mm Hg，P=0.038]，TyG指数高组24 h平均心率显著高于低组(P=0.002)。TyG指数高组ba-PWV显著高于低组(1 734.6±908.1) cm/s vs. (1 560.2±312.5) cm/s，P=0.022]。多元线性回归分析显示年龄、24小时平均收缩压及TyG指数是ba-PWV的影响因素。  结论  TyG指数与血压、心率和ba-PWV正相关。TyG指数可在临床实践中用于预测动脉硬化情况。 

Relationship between fasting triglyceride glucose index and arteriosclerosis in patients with essential hypertension

  Objective  To study the ambulatory blood pressure and brachial-ankle pulse wave velocity (ba-PWV) in essential hypertension patients with different fasting triglyceride glucose index (TyG index) groups, and to explore the correlation between TyG index and ba-PWV.  Methods  This retrospective study selected 466 inpatients with essential hypertension from August 2014 to December 2015. According to TyG index, the patients were divided into three groups by trisection. The differences of ambulatory blood pressure and ba-PWV among the three groups were compared, and the influencing factors of ba-PWV were analyzed by multiple linear regression model.  Results  With the increase of TyG index, the ratios of hyperlipidemia and diabetes of the patients raised, the average BMI increased, and the levels of total cholesterol, triglyceride, low density lipoprotein cholesterol, uric acid and fasting blood glucose evaluated gradually. The average systolic and diastolic blood pressure of 24 hours in the highest TyG index group were significantly higher than those in the lowest TyG index group (132.3±14.8) mm Hg vs. (127.0±14.9) mm Hg, P=0.003; (81.1±11.8) mm Hg vs. (77.8±11.5) mm Hg, P=0.038], the average heart rate of 24 hours in the highest TyG index group was significantly higher than that in the lowest TyG index group (P=0.002). Ba-PWV was significantly higher in the highest TyG index group than that in the lowest TyG index group (1 734.6±908.1) cm/s vs. (1 560.2±312.5) cm/s, P=0.022]. Multiple linear regression analysis showed that age, 24-hour systolic blood pressure and TyG index were the affecting factors of ba-PWV.  Conclusion  TyG index was positively correlated with blood pressure, heart rate and ba-PWV. It can be used to predict atherosclerosis in clinical practice.