雾化吸入乙酰半胱氨酸联合布地奈德治疗婴幼儿肺炎临床疗效观察

目的 探究雾化吸入乙酰半胱氨酸溶液联合布地奈德治疗婴幼儿肺炎的临床疗效及对炎性因子的影响.方法 选取2019年7月-2020年8月萧县人民医院收治的婴幼儿肺炎患儿66例,根据用药方案分为观察组(35例)和对照组(31例).对照组予以基础对症治疗和雾化吸入布地奈德治疗,2 mL/次,2次/d,连续使用7 d;观察组在对照...

Clinical effect and inflammatory factor analysis of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia

  Objective  To explore the clinical effect of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia and its effect on inflammatory factors.   Methods  Sixty-six infants and young children with pneumonia admitted to the hospital from July 2019 to August 2020 were selected. They were divided into the control group (n=31) and observation group (n=35) according to the drug regimen. The control group was treated with basic symptomatic treatment and 2 mL of budesonide twice a day for 7 days. On the basis of treatment of the control group, the observation group was treated with combined atomisation inhalation of 0.3 g acetylcysteine solution twice a day for 7 days. The clinical efficacy, disappearance time of clinical symptoms and occurrence of adverse reactions in both groups were compared, and the differences of serum inflammatory factors and lung function indicators in both groups before and after treatment were compared.   Results  The total effective rate (88.57%) of the observation group was higher than that of the control group (64.52%, χ2=5.147, P=0.020). The disappearance time of clinical symptoms and the temperature recovery time in the observation group were obviously shorter than those in the control group (all P < 0.05). The incidence of adverse reactions in both groups showed no significant difference (P>0.05). Serum interferon-γ, interleukin-6, interleukin-2, procalcitonin and C-reactive protein in both groups were significantly lower after treatment than before treatment, but the levels of inflammatory factors in the observation group were remarkably lower than those in the control group (all P < 0.05). The lung function indexes of both groups were significantly improved after treatment compared with those before treatment, and the improvement was more obvious in the observation group than in the control group (all P < 0.05).   Conclusion  Nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia has significant clinical efficacy. It can significantly shorten the disappearance time of various symptoms, reduce serum inflammation factors and help restore lung function. Moreover, it is relatively safe and is worthy of clinical promotion.