脂蛋白相关磷脂酶A2与颈动脉粥样硬化病变程度的相关性研究

  目的  探索脂蛋白相关磷脂酶A2(lipoprotein phospholipase A2, Lp-PLA2)与颈动脉粥样硬化病变程度的相关性及临床意义。  方法  选取2019年10月—2020年4月安徽省立医院收住行Lp-PLA2检测和颈动脉评估的227例患者，按照颈动脉粥样硬化程度分为3组，无明显颈动脉狭窄为对照组(58例)，颈动脉狭窄＜50%为颈动脉粥样硬化组(119例)，颈动脉狭窄≥50%为颈动脉狭窄组(50例)；按照有无新发心血管事件分为无新发事件组(154例)和新发事件组(73例)。检测Lp-PLA2及其他常规入院检验，分析各指标与颈动脉粥样硬化程度的关系，采用多元线性回归模型分析颈动脉粥样硬化病变的相关因素。  结果  与对照组Lp-PLA2(89.29±41.15)ng/mL]相比，颈动脉粥样硬化组(103.92±37.90)ng/mL]与颈动脉狭窄组(121.96±41.27)ng/mL]Lp-PLA2明显升高(均P＜0.05)；新发事件组Lp-PLA2(114.93±36.50)ng/mL]显著高于无新发事件组(98.76±42.47)ng/mL，P＜0.05]。多元线性回归分析结果表明，Lp-PLA2是颈动脉粥样硬化的独立影响因素。  结论  Lp-PLA2与颈动脉粥样硬化病变程度具有相关性，且随着颈动脉粥样硬化程度的加深，血清Lp-PLA2浓度同步升高。 

Relationship between lipoprotein-associated phospholipase A2 with degree of carotid atherosclerosis

  Objective  To investigate the correlation and clinical significance of lipoprotein phospholipase A2 (Lp-PLA2) with the extent of atherosclerosis in carotid arteries.  Methods  A total of 227 patients admitted at Anhui Provincial Hospital from October 2019 to April 2020 were included in this study. Patients were divided into three groups according to the degree of carotid artery atherosclerosis, namely, control group (no significant carotid stenosis, n=58), carotid atherosclerosis group (carotid artery stenosis < 50%, n=119) and carotid stenosis group (carotid stenosis≥50%, n=50). According to whether there are new cardiovascular events, they were divided into no new event group (154 cases) and new event group (73 cases). The levels of Lp-PLA2 and other conventional indicators were detected in all subjects, and the relationship between their levels and degree of carotid atherosclerosis was analysed, and analyzing the factors associated with carotid atherosclerotic lesions using multiple linear regression models.  Results  Compared with the control group (89.29±41.15) ng/mL], Lp-PLA2 was significantly increased in the carotid atherosclerosis group (103.92±37.90) ng/mL] and carotid stenosis group (121.96±41.27) ng/mL, all P < 0.05]. Lp-PLA2 in the new event group (114.93±36.50) ng/mL] was significantly higher than that in the no new event group (98.76±42.47) ng/mL, P < 0.05]. Linear regression analysis showed that Lp-PLA2 was an independent risk factor for carotid atherosclerosis.  Conclusion  Lp-PLA2 was correlated with the degree of carotid atherosclerosis. The serum Lp-PLA2 concentration increased with the gradual deepening of carotid atherosclerosis.