丁丙诺啡透皮贴剂在肩关节镜下肩袖修补术后的镇痛效果及安全性

目的 探究丁丙诺啡透皮贴剂(TBP)抑制肩袖修补术后疼痛的效果及药物不良反应.方法 回顾分析2017年10月-2019年10月在浙江医院行单侧肩关节镜下肩袖修补术后未接受和接受TBP止痛治疗患者(各30例)的临床资料,分为A、B 2组.A组患者术后应用氟比洛芬酯100 mg每日2次镇痛至术后5 d;B组患者术前1d应用...

The efficacy and safety of transdermal buprenorphine patch for postoperative analgesia after arthroscopic rotator cuff repair

  Objective  To explore the effect of transdermal buprenorphine patch (TBP) for postoperative analgesia after arthroscopic rotator cuff repair (ARCR) and to count the incidence of adverse drug reactions (ADR).  Methods  The clinical data of patients (30 cases in each group) who did not receive and received buprenorphine transdermal patch after ARCR under arthroscope in Zhejiang hospital from October 2017 to October 2019 were retrospectively analyzed. Group A were only treated with flurbiprofen axetil (FA) 100 mg twice a day for 5 days postoperatively. Group B were treated with FA as in A group postoperatively and 5mg TBP for 14 days (from 1 day before operation). The visual analogue score (VAS) of each group was tracked 1 day before operation and 1, 2, 3, 5 and 14 day after operation, and the incidence of ADR was counted. The simple shoulder test score (SST), range of shoulder forward elevation (FE) and external rotation (ER) were recorded, and compared between the same patients preoperatively and postoperatively and compared also between two groups.The statistical data was analyzed with t-test, analysis of variance and chi-squared test.  Results  On 3, 5 and 14 day after operation, the VAS of group B was lower than that of group A (P < 0.05).At 12 weeks follow-up, compared with preoperative values, the VAS, SST, FE and ER of two groups were significantly improved (P < 0.05). At 12 weeks, group B showed a larger FE range compared with group A (P < 0.05), while the difference of VAS, SST and ER between two groups had no statistical significance. The ADR of group A and group B was 2/30 (6.67%) and 5/30 (16.67%). No significant difference was found between two groups.  Conclusion  TBP has good effect for postoperative analgesia after ARCR and does not delay the recovery of shoulder joint function.