| 自噬相关基因及信号通路在口腔肿瘤发生发展中的影响 |
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| 引用本文： | 薛瑞,高继萍,闫晓如,续国强,宋国华. 自噬相关基因及信号通路在口腔肿瘤发生发展中的影响[J]. 肿瘤防治研究, 2021, 48(5): 514-518. DOI: 10.3971/j.issn.1000-8578.2021.20.1377 |
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| 作者姓名： | 薛瑞 高继萍 闫晓如 续国强 宋国华 |
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| 作者单位： | 1. 030001 太原，山西医科大学实验动物中心，实验动物与人类疾病动物模型山西省重点实验室；2. 030001 太原，山西医科大学附属精神卫生医院生物精神病学重点实验室 |
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| 基金项目： | 国家自然科学基金（31772551, 31970513） |
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| 摘 要： | 自噬是依赖溶酶体进行的一种高保守的细胞自我保护行为,可作为促进或预防癌症的重要因素.自噬作用与肿瘤的类型及发展程度相关,对自噬途径的了解有助于提高肿瘤的诊断和治疗.研究表明自噬与口腔肿瘤的发生发展密切相关,自噬相关基因及信号通路对口腔肿瘤起着双重调节作用.本文综述了在口腔肿瘤中自噬相关调节机制及治疗作用的最新进展.
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| 关 键 词： | 自噬相关基因 信号通路 口腔肿瘤 |
| 收稿时间： | 2020-11-27 |
Effects of Autophagy-related Genes and Signal Pathways on Occurrence andDevelopment of Oral Tumors |
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| XUE Rui,GAO Jiping,YAN Xiaoru,XU Guoqiang,SONG Guohua. Effects of Autophagy-related Genes and Signal Pathways on Occurrence andDevelopment of Oral Tumors[J]. Cancer Research on Prevention and Treatment, 2021, 48(5): 514-518. DOI: 10.3971/j.issn.1000-8578.2021.20.1377 |
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| Authors: | XUE Rui GAO Jiping YAN Xiaoru XU Guoqiang SONG Guohua |
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| Affiliation: | 1. Experimental Animal Center of Shanxi Medical University, Key Laboratory of Experimental Animals and Animal Models of Human Diseases in Shanxi Province, Taiyuan 030001, China; 2. Key Laboratory of Biological Psychiatry, Mental Health Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Autophagy is a highly conservative cellular self-protective behavior dependent on lysosomes, and can be used as an important factor in promoting or preventing cancer, and its effect is related to the type and development of tumors. A full understanding of autophagy pathway is helpful to improve the diagnosis and treatment of tumors. Studies have shown that autophagy is closely related to the occurrence and development of oral tumors. Autophagy-related genes and signal pathways play a dual regulatory role on oral tumors. This article reviews the latest progress in the regulatory mechanism and therapeutic effect of autophagy on oral tumors. |
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| Keywords: | Autophagy-related gene Signaling pathway Oral carcinoma |
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